Publication Name	World Journal of Meta-Analysis
Manuscript ID	51457
Country	Sri Lanka

Received	2019-09-17 08:14
Peer-Review Started	2019-09-17 08:14
To Make the First Decision	2019-11-15 01:00
Return for Revision	2019-11-19 09:08
Revised	2020-01-14 18:11
Second Decision	2020-02-27 08:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-02-28 06:46
Articles in Press	2020-02-28 06:46
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-03-06 01:01
Typeset the Manuscript	2020-03-23 01:25
Publish the Manuscript Online	2020-04-28 11:19

ISSN	2308-3840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Hypoxia and oxidative stress: The role of the anaerobic gut, the hepatic arterial buffer response and other defence mechanisms of the liver
Manuscript Source	Unsolicited Manuscript
All Author List	Samapriya Pasan Hewawasam
ORCID	Author(s) ORCID Number Samapriya Pasan Hewawasam http://orcid.org/0000-0002-9894-4661
Funding Agency and Grant Number
Corresponding Author	Samapriya Pasan Hewawasam, MBBS, MD, Freelancing Philosopher, Senior Lecturer, Department of Physiology, Faculty of Medicine, University of Ruhuna, Karapitiya, Galle 80000, Sri Lanka. spasanhewawasam@yahoo.com
Key Words	Anaerobic gut lumen; Oxidative stress; Liver defences against oxidative stress; Hepatic arterial buffer response; Hypoxia; Liver function
Core Tip	This review presents a prototypic view of the role of hypoxia as a regulator and a defence mechanism against oxidative stress in the gastrointestinal tract, including in the liver. The functional significance of having an anaerobic gut lumen for the preservation of energy sources is described in the article. Further, the significance of the hepatic arterial buffer response in the maintenance of the hypoxic microenvironment of hepatocytes to regulate the oxidative stress generated by the enormous catalytic potential of the liver and other hypoxia-mediated defences against this oxidative stress are described here.
Publish Date	2020-04-28 11:19
Citation	Hewawasam SP. Hypoxia and oxidative stress: The role of the anaerobic gut, the hepatic arterial buffer response and other defence mechanisms of the liver. World J Meta-Anal 2020; 8(2): 78-88
URL	https://www.wjgnet.com/2308-3840/full/v8/i2/78.htm
DOI	https://dx.doi.org/10.13105/wjma.v8.i2.78

Full Article (PDF)	WJMA-8-78.pdf
Full Article (Word)	WJMA-8-78.docx
Manuscript File	51457-Review-Webster J.docx
Answering Reviewers	51457-Answering reviewers.pdf
Audio Core Tip	51457-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	51457-Conflict-of-interest statement.pdf
Copyright License Agreement	51457-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	51457-Language certificate.pdf
Peer-review Report	51457-Peer-review(s).pdf
Scientific Misconduct Check	51457-Scientific misconduct check.pdf
Scientific Editor Work List	51457-Scientific editor work list.pdf