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Publication Name World Journal of Gastroenterology
Manuscript ID 51585
Country of Manuscript Source China
Received
2019-11-22 14:53
Peer-Review Started
2019-11-21 11:38
To Make the First Decision
Return for Revision
2019-12-23 14:02
Revised
2020-01-08 06:48
Second Decision
2020-01-11 01:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-14 19:32
Articles in Press
2020-01-14 19:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-29 08:03
Typeset the Manuscript
2020-02-10 07:25
Publish the Manuscript Online
2020-02-14 11:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study
Manuscript Source Invited Manuscript
All Author List Zhu-Jun Cao, Yu-Han Liu, Chuan-Wu Zhu, Shan Yin, Wei-Jing Wang, Wei-Liang Tang, Gang-De Zhao, Yu-Min Xu, Lu Chen, Tian-Hui Zhou, Ming-Hao Cai, Hui Wang, Wei Cai, Shi-San Bao, Hai Li and Qing Xie
ORCID
Author(s) ORCID Number
Zhu-Jun Cao http://orcid.org/0000-0002-8684-2107
Yu-Han Liu http://orcid.org/0000-0002-7910-6750
Chuan-Wu Zhu http://orcid.org/0000-0002-9113-2046
Shan Yin http://orcid.org/0000-0001-9483-6615
Wei-Jing Wang http://orcid.org/0000-0003-1612-0237
Wei-Liang Tang http://orcid.org/0000-0002-2460-2677
Gang-De Zhao http://orcid.org/0000-0002-2469-3695
Yu-Min Xu http://orcid.org/0000-0002-5114-2581
Lu Chen http://orcid.org/0000-0003-1845-1320
Tian-Hui Zhou http://orcid.org/0000-0002-4030-0206
Ming-Hao Cai http://orcid.org/0000-0001-9278-3919
Hui Wang http://orcid.org/0000-0002-1440-8942
Wei Cai http://orcid.org/0000-0001-9324-5987
Shi-San Bao http://orcid.org/0000-0002-6687-3846
Hai Li http://orcid.org/0000-0002-2510-5103
Qing Xie http://orcid.org/0000-0002-2582-8803
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81570535
National Natural Science Foundation of China 81770587
Key Projects in the National Science & Technology Pillar Program during the Thirteenth Five-year Plan Period 2017ZX10203201-008
Key Projects in the National Science & Technology Pillar Program during the Thirteenth Five-year Plan Period 2018ZX09206005-003
Key Projects in the National Science & Technology Pillar Program during the Thirteenth Five-year Plan Period 2017ZX10202202-005-004
Shanghai Three-Year Plan of the Clinical Skills and Innovations 16CR1002A
Shanghai Clinical Key Specialty Construction Project (Infectious Diseases) shslczdzk01103;
Shanghai Three-Year Plan of the Key Subjects Construction in Public Health-Infectious Diseases and Pathogenic Microorganism 15GWZK0102
Suzhou Expert Team of Clinical Medicine SZYJTD201717
Joint Research Initiative-Shanghai Jiao Tong University School of Medicine and the Shanghai Municipal Key Clinical Specialty-Infectious disease YW20190002
Corresponding author Qing Xie, MD, PhD, Chief Physician, Professor, Department of Infectious diseases, Shanghai Jiaotong University, School of Medicine, No. 36 Building, No.197 Ruijin 2nd Road, Shanghai 200025, China. xq10403@rjh.com.cn
Keywords Hepatitis B virus; Cirrhosis; Decompensation; Bacterial infection; Acute-on-chronic liver failure; Survival
Core Tip In our cohort of 1281 patients with hepatitis B virus-related decompensated cirrhosis, bacterial infection (BI) significantly reduced both short-term and long-term survival independently of the presence of Acute-on-chronic liver failure (ACLF) and the severity of the underlying liver disease. BI would precipitate ACLF in patients admitted without this syndrome and in those with ACLF, BI was significantly associated with the reduced rate of liver transplantation. Thus, the data suggests that patients with hepatitis B virus-DC should be monitored carefully for the development of BI to avoid an adverse outcome.
Publish Date 2020-02-14 11:49
Citation Cao ZJ, Liu YH, Zhu CW, Yin S, Wang WJ, Tang WL, Zhao GD, Xu YM, Chen L, Zhou TH, Cai MH, Wang H, Cai W, Bao SS, Li H, Xie Q. Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study. World J Gastroenterol 2020; 26(6): 645-656
Url https://www.wjgnet.com/1007-9327/full/v26/i6/645.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i6.645
Full Article (PDF) WJG-26-645.pdf
Full Article (Word) WJG-26-645.docx
Manuscript File 51585-Review_WangTQ.docx
Answering Reviewers 51585-Answering reviewers.pdf
Audio Core Tip 51585-Audio core tip.mp3
Biostatistics Review Certificate 51585-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51585-Conflict-of-interest statement.pdf
Copyright License Agreement 51585-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51585-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 51585-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 51585-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51585-Language certificate.pdf
Supplementary Material 51585-Supplementary material.pdf
Peer-review Report 51585-Peer-review(s).pdf
Scientific Misconduct Check 51585-Scientific misconduct check.pdf
Scientific Editor Work List 51585-Scientific editor work list.pdf