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Publication Name World Journal of Gastroenterology
Manuscript ID 51934
Country of Manuscript Source China
2019-10-09 21:09
Peer-Review Started
2019-10-09 21:10
To Make the First Decision
Return for Revision
2019-12-05 22:31
2019-12-20 05:20
Second Decision
2020-01-06 11:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-08 17:16
Articles in Press
2020-01-08 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-15 01:57
Typeset the Manuscript
2020-02-05 05:58
Publish the Manuscript Online
2020-02-07 13:14
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title lncRNACNN3-206 activates intestinal epithelial cells apoptosis and invasion by sponging miR-212, implication for Crohn's disease
Manuscript Source Unsolicited Manuscript
All Author List Na Li and Rui-Hua Shi
Author(s) ORCID Number
Na Li http://orcid.org/0000-0003-0926-0697
Rui-Hua Shi http://orcid.org/0000-0003-4977-8801
Funding Agency and Grant Number
Funding Agency Grant Number
Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX18_0174
Corresponding author Rui-Hua Shi, MD, PhD, Academic Research, Chief Doctor, Professor, Department of Gastroenterology, Southeast University,Zhongda Hospital, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China. ruihuashi@126.com
Keywords Crohn’s disease; Microarray; lncRNACNN3-206; Gene regulation; Cell migration and invasion; miR-212
Core Tip We described new findings on overexpression of lncRNACNN3-206 in intestinal lesions of Crohn’s disease (CD) patients by High throughput sequencing. Moreover, forced overexpression lncRNACNN3-206 led to apoptosis of Caco-2 and HT-29 cell lines. Since the 3'-end of lncRNACNN3-206 and the 3’-UTR of Caspase10 contain high affinity binding sites of miR-212, in which lncRNACNN3-206 regulated Caspase10 expression and cell apoptosis/invasion through sponging of miR-212. This mechanism was supported by results from cell lines and the mouse CD model. It was concluded that lncRNACNN3-206 may play a key role in CD pathogenesis, and it could be a therapeutic target for CD treatment.
Publish Date 2020-02-07 13:14
Citation Li N, Shi RH. lncRNACNN3-206 activates intestinal epithelial cells apoptosis and invasion by sponging miR-212, implication for Crohn's disease. World J Gastroenterol 2020; 26(5): 478-498
Url https://www.wjgnet.com/1007-9327/full/v26/i5/478.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i5.478
Full Article (PDF) WJG-26-478.pdf
Full Article (Word) WJG-26-478.docx
Manuscript File 51934-Review-Filipodia.doc
Answering Reviewers 51934-Answering reviewers.pdf
Audio Core Tip 51934-Audio core tip.m4a
Biostatistics Review Certificate 51934-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51934-Conflict-of-interest statement.pdf
Copyright License Agreement 51934-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 51934-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 51934-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51934-Language certificate.pdf
Supplementary Material 51934-Supplementary material.pdf
Peer-review Report 51934-Peer-review(s).pdf
Scientific Misconduct Check 51934-Scientific misconduct check.pdf
Scientific Editor Work List 51934-Scientific editor work list.pdf