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Publication Name World Journal of Gastroenterology
Manuscript ID 52299
Country/Territory Greece
2019-11-01 17:35
Peer-Review Started
2019-11-01 17:36
To Make the First Decision
Return for Revision
2019-11-22 01:56
2019-12-19 22:51
Second Decision
2019-12-30 07:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-01 22:58
Articles in Press
2020-01-01 22:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-01-08 02:06
Publish the Manuscript Online
2020-01-13 11:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Meta-Analysis
Article Title Diagnostic and clinical significance of antigen-specific pancreatic antibodies in inflammatory bowel diseases: A meta-analysis
Manuscript Source Invited Manuscript
All Author List Konstantinos Gkiouras, Maria G Grammatikopoulou, Xenophon Theodoridis, Eirini Pagkalidou, Evangelia Chatzikyriakou, Anna G Apostolidou, Eirini I Rigopoulou, Lazaros I Sakkas and Dimitrios Petrou Bogdanos
Author(s) ORCID Number
Konstantinos Gkiouras http://orcid.org/0000-0002-6407-8494
Maria G Grammatikopoulou http://orcid.org/0000-0003-4167-6595
Xenophon Theodoridis http://orcid.org/0000-0001-9810-7583
Eirini Pagkalidou http://orcid.org/0000-0002-8655-7293
Evangelia Chatzikyriakou http://orcid.org/0000-0002-5461-3633
Anna G Apostolidou http://orcid.org/0000-0001-8012-3454
Eirini I Rigopoulou http://orcid.org/0000-0003-1978-4602
Lazaros I Sakkas http://orcid.org/0000-0002-7670-3314
Dimitrios Petrou Bogdanos http://orcid.org/0000-0002-9697-7902
Funding Agency and Grant Number
Corresponding author Dimitrios Petrou Bogdanos, MD, PhD, Assistant Professor, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences,University of Thessaly, Biopolis, P.O. Box 1425, Larissa GR41110, Greece. bogdanos@med.uth.gr
Keywords Inflammatory bowel disease; Gastrointestinal disease; Evidence-based diagnosis; Sensitivity; Specificity; Ulcerative colitis
Core Tip The majority of individual studies assessing the diagnostic accuracy of autoantibodies for anti-glycoprotein 2 (anti-GP2) for Crohn’s disease (CD) diagnosis either include asymptomatic participants, or patients with symptoms not akin to CD. Most studies carry industry-related conflicts-of-interest, employing non-blinded evaluation of their assays and CD diagnosis preceding anti-GP2 testing. The pooled analyses performed herein using only symptomatic patients as controls, revealed high heterogeneity and low diagnostic accuracy of the anti-GP2, demonstrating low sensitivity and high specificity. Based on the pooled sensitivity and specificity of the anti-GP2 for CD diagnosis, they do not appear to attain the characteristics to be used per se as a proper non-invasive diagnostic tool.
Publish Date 2020-01-13 11:27
Citation Gkiouras K, Grammatikopoulou MG, Theodoridis X, Pagkalidou E, Chatzikyriakou E, Apostolidou AG, Rigopoulou EI, Sakkas LI, Bogdanos DP. Diagnostic and clinical significance of antigen-specific pancreatic antibodies in inflammatory bowel diseases: A meta-analysis. World J Gastroenterol 2020; 26(2): 246-265
Url https://www.wjgnet.com/1007-9327/full/v26/i2/246.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i2.246
Full Article (PDF) WJG-26-246.pdf
Full Article (Word) WJG-26-246.docx
Manuscript File 52299-Review.docx
Answering Reviewers 52299-Answering reviewers.pdf
Audio Core Tip 52299-Audio core tip.m4a
Biostatistics Review Certificate 52299-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52299-Conflict-of-interest statement.pdf
Copyright License Agreement 52299-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 52299-Language certificate.pdf
Peer-review Report 52299-Peer-review(s).pdf
Scientific Misconduct Check 52299-Scientific misconduct check.pdf
Scientific Editor Work List 52299-Scientific editor work list.pdf