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3/21/2020 2:52:57 AM | Browse: 26 | Download: 21
Publication Name World Journal of Gastroenterology
Manuscript ID 52704
Country/Territory Thailand
2019-11-18 06:38
Peer-Review Started
2019-11-18 06:39
To Make the First Decision
Return for Revision
2020-01-19 19:23
2020-02-06 09:05
Second Decision
2020-03-04 14:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-05 07:21
Articles in Press
2020-03-05 07:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-16 00:31
Publish the Manuscript Online
2020-03-21 02:52
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague–Dawley rats
Manuscript Source Invited Manuscript
All Author List Nasisorn Suksridechacin, Punnisa Kulwong, Siriporn Chamniansawat and Narongrit Thongon
Author(s) ORCID Number
Nasisorn Suksridechacin http://orcid.org/0000-0002-0236-6650
Punnisa Kulwong http://orcid.org/0000-0002-1786-3545
Siriporn Chamniansawat http://orcid.org/0000-0003-2609-6373
Narongrit Thongon http://orcid.org/0000-0003-2475-9161
Funding Agency and Grant Number
Funding Agency Grant Number
Burapha University through National Research Council of Thailand 15/2562
Corresponding author Narongrit Thongon, PhD, Associate Professor, Division of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, Saensook, Muang 20131, Chonburi, Thailand. narongritt@buu.ac.th
Keywords Adverse effect; Colon; Mg2+ absorption; Proton pump inhibitors-induced hypomagnesemia; Small intestine;
Core Tip Proton pump inhibitors (PPIs) induced hypomagnesemia (PPIH) has attracted attention in the past decade. Previous studies proposed that PPIH is a consequence of intestinal Mg2+ malabsorption. However, the effect of prolonged PPI administration on duodenal, jejunal, ileal, and colonic Mg2+ absorption is largely unknown. In this study, the rats received 20 mg/ kg·d subcutaneous omeprazole injection for 12 and 24 wk, which is comparable to 5 and 10 human years, respectively. Omeprazole injection induced hypomagnesemia with reduced urinary Mg2+ excretion. The rates of total, paracellular, and transcellular Mg2+ absorption reduced in the duodenum, jejunum, ilium, and colon were discovered in PPIH rats.
Publish Date 2020-03-21 02:52
Citation Nasisorn Suksridechacin, Punnisa Kulwong, Siriporn Chamniansawat, Narongrit Thongon. Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague–Dawley rats. World J Gastroenterol 2020; 26(11): 1142-1155
Url https://www.wjgnet.com/1007-9327/full/v26/i11/1142.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i11.1142
Full Article (PDF) WJG-26-1142.pdf
Full Article (Word) WJG-26-1142.docx
Manuscript File 52704-Review.docx
Answering Reviewers 52704-Answering reviewers.pdf
Audio Core Tip 52704-Audio core tip.mp3
Biostatistics Review Certificate 52704-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52704-Conflict-of-interest statement.pdf
Copyright License Agreement 52704-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52704-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52704-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 52704-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52704-Language certificate.pdf
Peer-review Report 52704-Peer-review(s).pdf
Scientific Misconduct Check 52704-Scientific misconduct check.pdf
Scientific Editor Work List 52704-Scientific editor work list.pdf