ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Retrospective Study |
Article Title |
Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers
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Manuscript Source |
Invited Manuscript |
All Author List |
Akiko Shida, Takashi Fukuyama, Nobue Futawatari, Yoshinobu Ichiki, Yatsushi Nishi, Noritada Kobayashi, Hitoshi Yamazaki, Masahiko Watanabe and Yoshihito Takahashi |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Grant-in-Aid for research by the Kitasato University Medical Center |
H26-008 |
Grant-in-Aid for research by the Kitasato University Medical Center |
H25-0006 |
JSPS KAKENHI |
17K16578 |
Takeda Science Foundation |
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Kitasato University Research Grant for Young Researchers |
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JSPS KAKENHI |
26670609 |
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Corresponding Author |
Takashi Fukuyama, PhD, Academic Research, Research Scientist, Division of Biomedical Research, Kitasato University Medical Center, Arai 6-100, Kitamoto 364-8501, Japan. fukuyam@insti.kitasato-u.ac.jp |
Key Words |
Gastric cancer; Tumor antigen; Cancer/testis antigen; Kita–Kyushu lung cancer antigen-1; Helicobacter pylori; Early detection of cancer |
Core Tip |
Kita–Kyushu lung cancer antigen-1 (KK-LC-1) is a relatively later cancer-testis antigen and is recently elevated the interest because Stevanovic et al. reported in Science 2017 that KK-LC-1 was predominant antigen for cancer immunotherapy. This study investigated that KK-LC-1 expression in gastric cancer (GC) relevant to ABCD stratification and its indexes to indicate the risk of GC appearing. KK-LC-1 expression was correlated with Helicobacter pylori, immunoglobulin G, and pepsinogen II. KK-LC-1 was frequently expressed group C of ABCD stratification, meaning that ABCD stratification would be also useful for GC expressing KK-LC-1, which is the target for cancer immunotherapy. |
Publish Date |
2020-01-18 06:08 |
Citation |
Shida A, Fukuyama T, Futawatari N, Omiya H, Ichiki Y, Yamashita T, Nishi Y, Kobayash N, Yamazaki H, Watanabe M, Takahashi Y. Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers. World J Gastroenterol 2020; 26(4): 424-432 |
URL |
https://www.wjgnet.com/1007-9327/full/v26/i4/424.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v26.i4.424 |