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4/14/2020 12:30:24 PM | Browse: 645 | Download: 1158
Publication Name World Journal of Gastroenterology
Manuscript ID 53067
Country/Territory China
Received
2019-12-12 02:43
Peer-Review Started
2019-12-12 02:44
To Make the First Decision
Return for Revision
2020-01-19 02:54
Revised
2020-01-20 15:34
Second Decision
2020-03-08 12:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-09 06:57
Articles in Press
2020-03-09 06:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-03-26 23:43
Typeset the Manuscript
2020-04-13 10:03
Publish the Manuscript Online
2020-04-14 12:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Opinion Review
Article Title Optimized timing of using infliximab in perianal fistulizing Crohn's disease
Manuscript Source Invited Manuscript
All Author List Xue-Liang Sun, Shi-Yi Chen, Shan-Shan Tao, Li-Chao Qiao, Hong-Jin Chen and Bo-Lin Yang
ORCID
Author(s) ORCID Number
Xue-Liang Sun http://orcid.org/0000-0001-8520-6937
Shi-Yi Chen http://orcid.org/0000-0003-1714-9867
Shan-Shan Tao http://orcid.org/0000-0002-8815-7146
Li-Chao Qiao http://orcid.org/0000-0002-0292-2936
Hong-Jin Chen http://orcid.org/0000-0003-2222-3582
Bo-Lin Yang http://orcid.org/0000-0002-2474-4085
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81673973
333 Project of Jiangsu Province, China LGY2019069
Developing Program for High-level Academic Talent in Jiangsu Hospital of TCM y2018rc16
Postgraduate Research and Practice Innovation Program of Jiangsu Province SJCX18_0510
Open Projects of the Discipline of Nanjing University of Chinese Medicine supported by Academic Priority discipline of Jiangsu Higher Education Institutions
Corresponding Author Bo-Lin Yang, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. yfy0051@njucm.edu.cn
Key Words Infliximab; Crohn’s disease; Perianal fistula; Optimization; Trough level; Deep remission
Core Tip The long-term outcomes of infliximab in the treatment of perianal fistulizing Crohn’s disease are unfavorable, due to loss of response. The optimization of the therapeutic strategy may increase clinical remission. Higher infliximab concentrations during induction are associated with a complete fistula response. Only patients in prolonged clinical remission should be considered for withdrawal of infliximab when biomarker, endoscopic and radiological remission is demonstrated. Fundamentally, the optimal timing of infliximab use is highly individualized and should be determined by a multidisciplinary team.
Publish Date 2020-04-14 12:30
Citation Sun XL, Chen SY, Tao SS, Qiao LC, Chen HJ, Yang BL. Optimized timing of using infliximab in perianal fistulizing Crohn's disease. World J Gastroenterol 2020; 26(14): 1554-1563
URL https://www.wjgnet.com/1007-9327/full/v26/i14/1554.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i14.1554
Full Article (PDF) WJG-26-1554.pdf
Full Article (Word) WJG-26-1554.docx
Manuscript File 53067-Review-Ma JY.docx
Answering Reviewers 53067-Answering reviewers.pdf
Audio Core Tip 53067-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 53067-Conflict-of-interest statement.pdf
Copyright License Agreement 53067-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53067-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 53067-Language certificate.pdf
Peer-review Report 53067-Peer-review(s).pdf
Scientific Misconduct Check 53067-Scientific misconduct check.pdf
Scientific Editor Work List 53067-Scientific editor work list.pdf