| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Na Yang, Li-Li Pang, Ji-Yuan Zhou, Yuan-Wang Qiu, Liang Miao, Shou-Yun Wang, Xiang-Zhong Liu, Kang-An Tan, Wan-Wan Shi, Gui-Qiang Wang and Feng-Qin Hou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81470849 |
| the China Mega-Project for Infectious Diseases |
2017ZX10203202 |
|
| Corresponding Author |
Feng-Qin Hou, MD, Associate Professor, Department of Infectious Diseases, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. houfqys@139.com |
| Key Words |
Drug-induced liver injury; Polygonum multiflorum; Single-nucleotide polymorphism; rs111686806; rs1055348; rs202047044 |
| Core Tip |
We aimed to identify single-nucleotide polymorphisms that indicate susceptibility to Polygonum multiflorum-induced liver injury (PM-DILI). We successfully identified three single-nucleotide polymorphisms, rs111686806 in the HLA-A gene, rs1055348 in the HLA-B gene and rs202047044 in the HLA-DRB1 gene to be associated with PM-DILI. Of which, rs1055348 had the strongest effect and was a specific risk factor to PM-DILI. We also validated the association between HLA-B*35:01 and PM-DILI. Furthermore, we analyzed the correlation between rs1055348 and HLA-B*35:01. With 100% sensitivity and > 95% specificity, rs1055348 may serve as a tag for HLA-B*35:01 and an alternative predictive biomarker for PM-DILI. |
| Publish Date |
2020-03-28 13:10 |
| Citation |
Yang WN, Pang LL, Zhou JY, Qiu YW, Miao L, Wang SY, Liu XZ, Tan KA, Shi WW, Wang GQ, Hou FQ. Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population. World J Gastroenterol 2020;26(12): 1329-1339 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i12/1329.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i12.1329 |
