Publication Name	World Journal of Gastroenterology
Manuscript ID	5315
Country	Italy

Received	2013-08-29 09:05
Peer-Review Started	2013-08-29 16:07
To Make the First Decision	2013-10-22 16:52
Return for Revision	2013-10-22 17:58
Revised	2013-10-30 23:23
Second Decision	2013-11-18 21:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-19 12:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-11 13:38
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Exploitation of host clock gene machinery by hepatitis viruses B and C
Manuscript Source	Invited Manuscript
All Author List	Manlio Vinciguerra, Gianluigi Mazzoccoli, Claudia Piccoli, Tiziana Tataranni, Angelo Andriulli and Valerio Pazienza
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Health RC1303GA49 (Pazienza V) Bando GR-2010-2311017 (to Vinciguerra M and Pazienza V) the “5x1000” voluntary contributions to IRCCS “Casa Sollievo della Sofferenza” Hospital to Vinciguerra M and Pazienza V Associazione Italiana per la Ricerca sul Cancro (AIRC) program MyFAG to Vinciguerra M
Corresponding Author	Dr. Valerio Pazienza, Gastroenterology Unit, IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo (FG), Italy. pazienza_valerio@yahoo.it
Key Words	Hepatitis C virus; Hepatitis B virus; Anti-hepatitis therapy; Clock genes; Chronobiology
Core Tip	New antiviral strategies have been developed, including the interferon/ribavirin-free therapy, to control hepatitis viruses replication. Although, IFN-free regimens have generated excitement among scientists, for the reason that they are better tolerated, they are not still able to completely eradicate the viruses. Here we underline the circadian relationship between host cell and hosted hepatitis viruses, that has to be taken into account in order to optimize the timing of therapeutic regimens, not only to minimize the pharmacological agents' toxicity but also to improve the efficacy of treatment modalities through optimized timing of therapeutic regimens, targeting in a better way virus replication.
Publish Date	2014-01-20 16:41
Citation	Vinciguerra M, Mazzoccoli G, Piccoli C, Tataranni T, Andriulli A, Pazienza V. Exploitation of host clock gene machinery by hepatitis viruses B and C. World J Gastroenterol 2013; 19(47): 8902-8909
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/8902.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.8902

Full Article (PDF)	WJG-19-8902.pdf
Manuscript File	5315-Review.docx
Answering Reviewers	5315-Answering reviewers.pdf
Copyright License Agreement	5315-Copyright assignment.pdf
Peer-review Report	5315-Peer review(s).pdf
Scientific Editor Work List	5315-Scientific editor work list.doc