Publication Name	World Journal of Biological Chemistry
Manuscript ID	5341
Country	Austria

Received	2013-08-31 18:59
Peer-Review Started	2013-09-02 16:01
To Make the First Decision	2013-10-28 16:09
Return for Revision	2013-10-29 10:49
Revised	2013-11-11 16:46
Second Decision	2013-11-18 17:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-19 11:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-26 12:14
Publish the Manuscript Online	2013-12-06 18:20

ISSN	1949-8454 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	High-density lipoprotein endocytosis in endothelial cells
Manuscript Source	Invited Manuscript
All Author List	Stefanie Fruhwürth, Margit Pavelka, Robert Bittman, Werner J Kovacs, Katharina M Walter, Clemens Röhrl and Herbert Stangl
Funding Agency and Grant Number	Funding Agency Grant Number Austrian Science Fund P20116-B13 Austrian Science Fund P22838-B13
Corresponding Author	Dr. Herbert Stangl, Center for Pathobiochemistry and Genetics, Institute of Medical Chemistry, Medical University of Vienna, W?hringerstrasse 10, 1090 Vienna, Austria. herbert.stangl@meduniwien.ac.at
Key Words	high-density lipoprotein; endocytosis; endothelium; human umbilical vein endothelial cells; human coronary artery endothelial cells; cholesterol
Core Tip	The cardio-protective effect of high-density lipoprotein (HDL) is related to its ability to transfer lipids from the periphery, such as atherosclerotic plaques, back to the liver for excretion. Therefore, HDL has to cross the endothelial barrier. In the present work we analyzed the steps and way stations of HDL uptake and resecretion using novel fluorescent cholesterol surrogates in human endothelial cells as a model for the endothelial barrier. HDL uptake occurred via clathrin-coated pits, tubular endosomes and multivesicular bodies in human umbilical vein endothelial cells. Finally we compared key findings to the in vivo situation.
Publish Date	2013-12-06 18:20
Citation	Fruhwürth S, Pavelka M, Bittman R, Kovacs WJ, Walter KM, R?hrl C, Stangl H. High-density lipoprotein endocytosis in endothelial cells. World J Biol Chem 2013; 4(4): 131-140
URL	http://www.wjgnet.com/1949-8454/full/v4/i4/131.htm
DOI	http://dx.doi.org/10.4331/wjbc.v4.i4.131

Full Article (PDF)	WJBC-4-131.pdf
Manuscript File	5341-Review.doc
Answering Reviewers	5341-Answering reviewers.pdf
Copyright License Agreement	5341-Copyright assignment.pdf
Peer-review Report	5341-Peer review(s).pdf
Scientific Editor Work List	5341-Scientific editor work list.doc