| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tatsuo Miyamura, Tatsuo Kanda, Masato Nakamura, Xia Jiang, Shuang Wu, Shingo Nakamoto, Shigeru Mikami, Nobuo Takada, Fumio Imazeki and Osamu Yokosuka |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan |
|
| Ministry of Health, Labour and Welfare of Japan |
|
|
| Corresponding Author |
Tatsuo Kanda, MD, PhD, Associate Professor, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan. kandat-cib@umin.ac.jp |
| Key Words |
Hepatitis C virus; Interleukin 28B; Persistent normal alanine aminotransferase levels; Standard of care; Treatment response |
| Core Tip |
Whether the interleukin 28B (IL-28B) genotype affects the treatment response to peginterferon plus ribavirin in hepatitis C virus (HCV)-infected patients with persistently normal alanine aminotransferase (PNALT) is unclear. We examined the association between the IL-28B genotype and treatment response in HCV-infected patients with PNALT. Opinions about the appropriate treatment method for HCV-infected patients with PNALT differ. In the present study, we found that IL-28B rs8099917 TT was associated with SVR in HCV genotype 1-infected Asian patients with PNALT. The determination of IL-28B genotype is important for the successful treatment of HCV genotype 1-infected patients with PNALT.
|
| Publish Date |
2013-11-26 22:03 |
| Citation |
Miyamura T, Kanda T, Nakamura M, Jiang X, Wu S, Nakamoto S, Mikami S, Takada N, Imazeki F, Yokosuka O. IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase. World J Hepatol 2013; 5(11): 635-641 |
| URL |
http://www.wjgnet.com/1948-5182/full/v5/i11/635.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v5.i11.635 |
