Publication Name	World Journal of Gastroenterology
Manuscript ID	53523
Country	Australia

Received	2019-12-23 05:47
Peer-Review Started	2019-12-23 05:47
To Make the First Decision
Return for Revision	2020-02-18 22:00
Revised	2020-03-10 20:33
Second Decision	2020-04-16 06:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-16 23:10
Articles in Press	2020-04-16 23:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-27 06:11
Publish the Manuscript Online	2020-04-28 08:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Macrophages in metabolic associated fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Jawaher Alharthi, Olivier Latchoumanin, Jacob George and Mohammed Eslam
ORCID	Author(s) ORCID Number Jawaher Alharthi http://orcid.org/0000-0003-4017-2926 Olivier Latchoumanin http://orcid.org/0000-0002-4388-2299 Jacob George http://orcid.org/0000-0001-8154-8278 Mohammed Eslam http://orcid.org/0000-0002-4315-4144
Funding Agency and Grant Number
Corresponding Author	Mohammed Eslam, MD, MSc, PhD, Assistant Professor, Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, 176 Hawkesbury Rd, Sydney 2145, NSW, Australia. mohammed.eslam@sydney.edu.au
Key Words	Metabolic associated fatty liver disease; Macrophages; Inflammation; Fibrosis; Hepatic stellate cells;
Core Tip	In this work, we review the recent advances in our understanding of macrophage biology during the entire spectrum of metabolic associated fatty liver disease (MAFLD) including steatosis, inflammation, fibrosis, and hepatocellular carcinoma, as well as for the extra-hepatic manifestations of MAFLD. We discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes, hepatic stellate cells and adipose tissue. We conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD.
Publish Date	2020-04-28 08:04
Citation	Alharthi J, Latchoumanin O, George J, Eslam M. Macrophages in metabolic associated fatty liver disease. World J Gastroenterol 2020; 26(16): 1861-1878
URL	https://www.wjgnet.com/1007-9327/full/v26/i16/1861.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i16.1861

Full Article (PDF)	WJG-26-1861.pdf
Full Article (Word)	WJG-26-1861.docx
Manuscript File	53523-Review.docx
Answering Reviewers	53523-Answering reviewers.pdf
Audio Core Tip	53523-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	53523-Conflict-of-interest statement.pdf
Copyright License Agreement	53523-Copyright license agreement.pdf
Peer-review Report	53523-Peer-review(s).pdf
Scientific Misconduct Check	53523-Bing-Tang JZ-2.png
Scientific Misconduct Check	53523-Scientific misconduct check.pdf
Scientific Editor Work List	53523-Scientific editor work list.pdf