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6/6/2020 2:43:56 PM | Browse: 88 | Download: 36
Publication Name World Journal of Gastroenterology
Manuscript ID 53534
Country/Territory Italy
2019-12-31 11:44
Peer-Review Started
2019-12-31 11:44
To Make the First Decision
Return for Revision
2020-02-24 22:54
2020-03-27 12:16
Second Decision
2020-05-26 08:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-27 00:27
Articles in Press
2020-05-27 00:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-06-04 00:24
Publish the Manuscript Online
2020-06-06 14:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biology
Manuscript Type Basic Study
Article Title Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine
Manuscript Source Invited Manuscript
All Author List Gregorio Di Franco, Alice Usai, Niccola Funel, Matteo Palmeri, Ida Elena Rosamaria Montesanti, Matteo Bianchini, Desirée Gianardi, Niccolò Furbetta, Simone Guadagni, Enrico Vasile, Alfredo Falcone, Luca Emanuele Pollina, Vittoria Raffa and Luca Morelli
Author(s) ORCID Number
Gregorio Di Franco http://orcid.org/0000-0003-2156-369X
Alice Usai http://orcid.org/0000-0003-0226-837X
Niccola Funel http://orcid.org/0000-0002-5028-2363
Matteo Palmeri http://orcid.org/0000-0002-9343-278X
Ida Elena Rosamaria Montesanti http://orcid.org/0000-0003-4760-5333
Matteo Bianchini http://orcid.org/0000-0002-2403-0621
Desirée Gianardi http://orcid.org/0000-0002-6238-9176
Niccolò Furbetta http://orcid.org/0000-0002-7135-2666
Simone Guadagni http://orcid.org/0000-0001-9072-8166
Enrico Vasile http://orcid.org/0000-0002-8482-6963
Alfredo Falcone http://orcid.org/0000-0001-5840-2529
Luca Emanuele Pollina http://orcid.org/0000-0001-7163-8050
Vittoria Raffa http://orcid.org/0000-0002-4289-9937
Luca Morelli http://orcid.org/0000-0002-7742-9556
Funding Agency and Grant Number
Funding Agency Grant Number
Fondazione Pisa 114/16
Corresponding author Luca Morelli, FACS, MD, Associate Professor, Surgeon, General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, Pisa 56124, Italy. luca.morelli@unipi.it
Key Words Pancreatic ductal adenocarcinoma; Zebrafish embryos; Personalized medicine; Xenotransplantation; Chemotherapy efficacy; Avatar of oncological patients
Core Tip Patient-derived xenograft model has emerged as an important tool for personalized medicine. Zebrafish embryos offer several advantages: the short generation time, the large number of offspring, the transparency, and the small size therefore making zebrafish a more practical and less expensive laboratory system than others in vivo cancer models. We developed a model to use zebrafish embryos as avatar of patients with pancreatic ductal adenocarcinoma, standardizing the protocol for the xenotransplantation of pancreatic tumor tissue, for the exposition of the xenotransplanted zebrafish embryos to the chemotherapy drugs, and for the evaluation of the effects of chemotherapy on the xenotransplanted tumor tissue.
Publish Date 2020-06-06 14:43
Citation Di Franco G, Usai A, Funel N, Palmeri M, Montesanti IER, Bianchini M, Gianardi D, Furbetta N, Guadagni S, Vasile E, Falcone A, Pollina LE, Raffa V, Morelli L. Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine. World J Gastroenterol 2020; 26(21): 2792-2809
Url https://www.wjgnet.com/1007-9327/full/v26/i21/2792.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i21.2792
Full Article (PDF) WJG-26-2792.pdf
Full Article (Word) WJG-26-2792.docx
Manuscript File 53534-Review.docx
Answering Reviewers 53534-Answering reviewers.pdf
Audio Core Tip 53534-Audio core tip.m4a
Biostatistics Review Certificate 53534-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53534-Conflict-of-interest statement.pdf
Copyright License Agreement 53534-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53534-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 53534-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 53534-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 53534-Language certificate.pdf
Peer-review Report 53534-Peer-review(s).pdf
Scientific Misconduct Check 53534-Bing-Dou Y-2.png
Scientific Misconduct Check 53534-Scientific misconduct check.pdf
Scientific Editor Work List 53534-Scientific editor work list.pdf