| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Gregorio Di Franco, Alice Usai, Niccola Funel, Matteo Palmeri, Ida Elena Rosamaria Montesanti, Matteo Bianchini, Desirée Gianardi, Niccolò Furbetta, Simone Guadagni, Enrico Vasile, Alfredo Falcone, Luca Emanuele Pollina, Vittoria Raffa and Luca Morelli |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondazione Pisa |
114/16 |
|
| Corresponding Author |
Luca Morelli, FACS, MD, Associate Professor, Surgeon, General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, Pisa 56124, Italy. luca.morelli@unipi.it |
| Key Words |
Pancreatic ductal adenocarcinoma; Zebrafish embryos; Personalized medicine; Xenotransplantation; Chemotherapy efficacy; Avatar of oncological patients |
| Core Tip |
Patient-derived xenograft model has emerged as an important tool for personalized medicine. Zebrafish embryos offer several advantages: the short generation time, the large number of offspring, the transparency, and the small size therefore making zebrafish a more practical and less expensive laboratory system than others in vivo cancer models. We developed a model to use zebrafish embryos as avatar of patients with pancreatic ductal adenocarcinoma, standardizing the protocol for the xenotransplantation of pancreatic tumor tissue, for the exposition of the xenotransplanted zebrafish embryos to the chemotherapy drugs, and for the evaluation of the effects of chemotherapy on the xenotransplanted tumor tissue. |
| Publish Date |
2020-06-06 14:43 |
| Citation |
Di Franco G, Usai A, Funel N, Palmeri M, Montesanti IER, Bianchini M, Gianardi D, Furbetta N, Guadagni S, Vasile E, Falcone A, Pollina LE, Raffa V, Morelli L. Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine. World J Gastroenterol 2020; 26(21): 2792-2809 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i21/2792.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i21.2792 |
