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4/7/2020 9:33:59 AM | Browse: 769 | Download: 1180
Publication Name World Journal of Biological Chemistry
Manuscript ID 53536
Country/Territory Spain
Received
2019-12-23 14:38
Peer-Review Started
2019-12-23 14:39
To Make the First Decision
2020-02-26 11:18
Return for Revision
2020-02-27 11:17
Revised
2020-03-18 12:03
Second Decision
2020-03-30 12:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-31 19:11
Articles in Press
2020-03-31 19:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-04-07 06:15
Publish the Manuscript Online
2020-04-07 09:33
ISSN 1949-8454 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Review
Article Title Why the discovery of adherent-invasive Escherichia coli molecular markers is so challenging?
Manuscript Source Invited Manuscript
All Author List Carla Camprubí-Font and Margarita Martinez-Medina
ORCID
Author(s) ORCID Number
Carla Camprubí-Font http://orcid.org/0000-0003-4901-4991
Margarita Martinez-Medina http://orcid.org/0000-0003-0177-3307
Funding Agency and Grant Number
Funding Agency Grant Number
Spanish Ministry of Economy and Competitiveness SAF2017-82261-P
Corresponding Author Margarita Martinez-Medina, PhD, Associate Professor, Laboratory of Molecular Microbiology, Department of Biology, Universitat de Girona, C/Maria Aurèlia Capmany, 40, Girona 17003, Spain. marga.martinez@udg.edu
Key Words Crohn’s disease; Adherent-invasive Escherichia coli; Molecular markers; Genetics; Inflammatory bowel disease; Signature sequences
Core Tip In this review, we thoroughly review the approaches for deciphering adherent-invasive Escherichia coli (AIEC) genetics. The characteristics of putative AIEC molecular markers that could assist in AIEC identification are described. We then discuss several aspects that could explain the difficulty behind the discovery of suitable biomarkers and highlight the importance of standardizing AIEC protocols in order to increase the probability of finding these biomarkers. Finally, we point out new approaches for looking for signature sequences that need to take into account the AIEC phylogenetic origin and strain virulence under particular experimental conditions.
Publish Date 2020-04-07 09:33
Citation Camprubí-Font C, Martinez-Medina M. Why the discovery of adherent-invasive Escherichia coli molecular markers is so challenging? World J Biol Chem 2020; In press
URL https://www.wjgnet.com/1949-8454/full/v11/i1/1.htm
DOI https://dx.doi.org/10.4331/wjbc.v11.i1.1
Full Article (PDF) WJBC-11-1.pdf
Full Article (Word) WJBC-11-1.docx
Manuscript File 53536-Review.docx
Answering Reviewers 53536-Answering reviewers.pdf
Audio Core Tip 53536-Audio core tip.wav
Conflict-of-Interest Disclosure Form 53536-Conflict-of-interest statement.pdf
Copyright License Agreement 53536-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53536-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 53536-Language certificate.pdf
Peer-review Report 53536-Peer-review(s).pdf
Scientific Misconduct Check 53536-Scientific misconduct check.pdf
Scientific Editor Work List 53536-Scientific editor work list.pdf