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Articles Published Processes
4/28/2020 8:04:30 AM | Browse: 801 | Download: 1445
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Received |
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2019-12-25 14:17 |
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Peer-Review Started |
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2019-12-25 14:19 |
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To Make the First Decision |
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Return for Revision |
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2020-01-19 00:48 |
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Revised |
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2020-01-24 19:31 |
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Second Decision |
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2020-04-03 13:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-04-04 02:55 |
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Articles in Press |
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2020-04-04 02:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-27 06:08 |
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Publish the Manuscript Online |
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2020-04-28 08:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tsvetelina Veselinova Velikova, Lyuba Miteva, Noyko Stanilov, Zoya Spassova and Spaska Angelova Stanilova |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical University of Sofia |
22/2012-2013 |
| Trakia University of Stara Zagora |
1.2016 |
| Trakia University of Stara Zagora |
2.2017 |
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| Corresponding Author |
Tsvetelina Veselinova Velikova, MD, PhD, Assistant Professor, Clinical Immunology, University Hospital Lozenetz, Kozyak 1 street, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg |
| Key Words |
Inflammatory bowel disease; Colorectal cancer; Cytokines; mRNA; Interleukin-6; Th17/Treg cells |
| Core Tip |
In our paper, we showed that IL-6 upregulation is essential for both inflammatory bowel disease and colorectal cancer (CRC) development, whereas the upregulation of other Th17/Treg related genes (TGFb1, IL-10, IL-23, and transcription factor FoxP3) is a crucial primarily for CRC development. The significantly upregulated IL-6 could be a potential drug target for inflammatory bowel disease and prevention of CRC development as well. |
| Publish Date |
2020-04-28 08:04 |
| Citation |
Velikova TV, Miteva L, Stanilov N, Spassova Z, Stanilova SA. Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer. World J Gastroenterol 2020; 26(16): 1912-1925 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i16/1912.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i16.1912 |
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