ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus
|
Manuscript Source |
Invited Manuscript |
All Author List |
Cliviany Borges da Silva, Diego Alves Vieira, Luisa Freitas de Melo, Anna Luiza Soares Chagas, Adriana Dias Gomes, César Lúcio Lopes de Faria Jr, Rosângela Teixeira, Dulciene Maria de Magalhães Queiroz, Gifone Aguiar Rocha, Maria Marta Sarquis Soares, Juliana Maria Trindade Bezerra and Luciana Diniz Silva |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
APQ-02320-18 |
|
Corresponding Author |
Luciana Diniz Silva, MD, PhD, Academic Research, Associate Professor, Attending Doctor, Research Scientist, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/255, Belo Horizonte 30720030, Minas Gerais, Brazil. lucianadinizsilva@gmail.com |
Key Words |
Chronic Hepatitis C; Type 2 diabetes mellitus; Interleukin 6-174G/C gene promoter single nucleotide polymorphism; Blood hypertension; Healthy control subjects; |
Core Tip |
Chronic hepatitis C is associated with type 2 diabetes mellitus. Previous studies have demonstrated associations between increased serum concentrations of Interleukin 6 (IL-6) and type 2 diabetes and advanced forms of liver disease. However, the role played by IL-6-174G/C single nucleotide polymorphism on the pathogenesis of hepatitis C virus-associated type 2 diabetes remains to be elucidated. To the best of our knowledge, this is the first study to demonstrate that the GC and GG genotypes of IL-6 are inversely associated with type 2 diabetes. We believe that our results may contribute to the understanding of the extra-hepatic manifestations in hepatitis C. |
Publish Date |
2020-04-23 10:34 |
Citation |
de Silva CB, Vieira DA, de Melo LF, Chagas ALS, Gomes AD, Faria Jr CLL, Teixeira R, Queiroz DM, Rocha GA, Soares MMS, de Bezerra JMT, Silva LD. Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus. World J Hepatol 2020; 12(4): 137-148 |
URL |
https://www.wjgnet.com/1948-5182/full/v12/i4/137.htm |
DOI |
https://dx.doi.org/10.4254/wjh.v12.i4.137 |