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Articles Published Processes
5/14/2020 3:43:04 AM | Browse: 732 | Download: 1234
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Received |
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2019-12-30 01:19 |
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Peer-Review Started |
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2019-12-30 01:20 |
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To Make the First Decision |
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Return for Revision |
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2020-03-27 00:23 |
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Revised |
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2020-04-08 03:21 |
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Second Decision |
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2020-04-24 09:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-04-24 17:19 |
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Articles in Press |
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2020-04-24 17:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-04-27 10:51 |
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Typeset the Manuscript |
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2020-05-13 00:55 |
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Publish the Manuscript Online |
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2020-05-14 03:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
New role for ceramide in hypoxia and insulin resistance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qing-Song Xia, Fu-Er Lu, Fan Wu, Zhao-Yi Huang, Hui Dong, Li-Jun Xu and Jing Gong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81904158 |
| TCM Modernization Research of National Key Research and Development Program |
2018YFC1704202 |
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| Corresponding Author |
Jing Gong, MD, Doctor, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan 430030, Hubei Province, China. jgongtcm@126.com |
| Key Words |
Ceramide; Intestinal hypoxia; Insulin resistance; Diabetes mellitus; Hypoxia-inducible factors; Obesity |
| Core Tip |
Hypoxia is an essential risk factor that promotes insulin resistance in a variety of tissues, such as adipocytes, intestines, liver, etc. In hypoxic adipocytes, hypoxia-inducible factor-1α upregulates pla2g16 gene expression to activate the NLRP3 inflammasome pathway, leading to insulin resistance. In obese animals or people, increased ceramide further results in insulin resistance under hypoxia. In intestinal epithelial cells, hypoxia-inducible factor-2α is activated and accumulates under hypoxia in high-fat diet-fed mice, which upregulates the target gene Neu3, accelerating the process of insulin resistance. |
| Publish Date |
2020-05-14 03:43 |
| Citation |
Xia QS, Lu FE, Wu F, Huang ZY, Dong H, Xu LJ, Gong J. New role for ceramide in hypoxia and insulin resistance. World J Gastroenterol 2020; 26(18): 2177-2186 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i18/2177.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i18.2177 |
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