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6/14/2020 1:45:26 PM | Browse: 89 | Download: 105
Publication Name World Journal of Gastroenterology
Manuscript ID 53733
Country/Territory China
Received
2019-12-30 10:23
Peer-Review Started
2019-12-30 10:23
To Make the First Decision
Return for Revision
2020-01-11 22:46
Revised
2020-04-29 14:35
Second Decision
2020-05-12 07:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-12 21:44
Articles in Press
2020-05-12 21:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-29 01:55
Typeset the Manuscript
2020-06-10 01:58
Publish the Manuscript Online
2020-06-14 13:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Control Study
Article Title Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk
Manuscript Source Invited Manuscript
All Author List Xiao-Yi Wang, Hai-Tao Chen, Rong Na, De-Ke Jiang, Xiao-Ling Lin, Feng Yang, Chen Jin, De-Liang Fu and Jian-Feng Xu
ORCID
Author(s) ORCID Number
Xiao-Yi Wang http://orcid.org/0000-0002-9714-3467
Hai-Tao Chen http://orcid.org/0000-0002-8490-5039
Rong Na http://orcid.org/0000-0001-7470-5108
De-Ke Jiang http://orcid.org/0000-0002-7888-2344
Xiao-Ling Lin http://orcid.org/0000-0001-9713-0343
Feng Yang http://orcid.org/0000-0001-8790-6072
Chen Jin http://orcid.org/0000-0002-4330-9716
De-Liang Fu http://orcid.org/0000-0003-1832-2000
Jian-Feng Xu http://orcid.org/0000-0002-9419-6627
Funding Agency and Grant Number
Corresponding author De-Liang Fu, MD, PhD, Doctor, Professor, Surgical Oncologist, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, No. 12, Central Urumqi Road, Shanghai 200040, China. fudeliang@huashan.org.cn
Key Words Pancreatic cancer; Single nucleotide polymorphisms; Genetic risk score; Chinese population; Genome-wide association study;
Core Tip Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with no effective method for early diagnosis and high-risk population screening. In this pioneer study, we evaluated single nucleotide polymorphisms based genetic risk score (GRS) in the prediction of PDAC risk. Our results revealed that GRS was significantly associated with PDAC (odd ratios: 1.39, 95% confidence interval: 1.03-1.84, P = 0.031). Compared with low GRS (< 1.0), subjects with high GRS (2.0) were 99% more likely to be PDAC (odd ratios: 1.99, 95% confidence interval: 1.30-3.04, P = 0.002). Although needed further verification, our study suggested that GRS was an independent risk factor for PDAC.
Publish Date 2020-06-14 13:45
Citation Wang XY, Chen HT, Na R, Jiang DK, Lin XL, Yang F, Jin C, Fu DL, Xu JF. Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk. World J Gastroenterol 2020; 26(22): 3076-3086
Url https://www.wjgnet.com/1007-9327/full/v26/i22/3076.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i22.3076
Full Article (PDF) WJG-26-3076.pdf
Full Article (Word) WJG-26-3076.docx
Manuscript File 53733-Review-Filipodia.docx
Answering Reviewers 53733-Answering reviewers.pdf
Audio Core Tip 53733-Audio core tip.mp3
Biostatistics Review Certificate 53733-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53733-Conflict-of-interest statement.pdf
Copyright License Agreement 53733-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 53733-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 53733-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 53733-Language certificate.pdf
Peer-review Report 53733-Peer-review(s).pdf
Scientific Misconduct Check 53733-Bing-Yan JP-2.png
Scientific Misconduct Check 53733-Scientific misconduct check.pdf
Scientific Editor Work List 53733-Scientific editor work list.pdf