| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Apichaya Khlaiphuengsin, Natthaya Chuaypen, Pimpayao Sodsai, Supranee Buranapraditkun, Tadech Boonpiyathad, Nattiya Hirankarn and Pisit Tangkijvanich |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Thailand Research Fund |
RTA6280004 |
| The Grant for Chula Research Scholar |
CU-GRS-61-07-30-02 |
| Second Century Fund (C2F), Chulalongkorn University |
|
| Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University |
|
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| Corresponding Author |
Pisit Tangkijvanich, MD, Doctor, Doctor, Professor, Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Pathumwan, Bangkok 10330, Thailand. pisittkvn@yahoo.com |
| Key Words |
B cells; Hepatitis B virus; Hepatocellular carcinoma; B cell-activating factor receptor; ; |
| Core Tip |
This study explored the expression of B cell-activating factor receptor (BAFF-R) and B cell subpopulations in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Our data showed that BAFF-R expression was significantly lower in patient with HCC compared with non-HCC and healthy controls. In addition, the frequencies of CD27+IgD+ memory B cells, CD27+IgD- class-switched memory B cells and plasmablasts were significantly lower in the patients with HCC compared to patients without HCC. In addition, decreased BAFF-R expression was significantly correlated with tumor size and tumor stage. This study is the first report suggesting that the depletion of BAFF-R in B cells might be responsible for B cell maturation in patients with HBV-related HCC. |
| Publish Date |
2020-05-28 13:08 |
| Citation |
Khlaiphuengsin A, Chuaypen N, Sodsai P, Buranapraditkun S, Boonpiyathad T, Hirankarn N, Tangkijvanich P. Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2020; 26(20): 2645-2656 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i20/2645.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i20.2645 |
