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5/28/2020 1:08:01 PM | Browse: 88 | Download: 79
Publication Name World Journal of Gastroenterology
Manuscript ID 54114
Country/Territory Thailand
Received
2020-01-27 06:12
Peer-Review Started
2020-02-03 03:37
To Make the First Decision
Return for Revision
2020-02-29 22:09
Revised
2020-03-27 08:04
Second Decision
2020-05-12 09:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-12 21:34
Articles in Press
2020-05-12 21:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-05-27 09:25
Publish the Manuscript Online
2020-05-28 13:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Retrospective Study
Article Title Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Apichaya Khlaiphuengsin, Natthaya Chuaypen, Pimpayao Sodsai, Supranee Buranapraditkun, Tadech Boonpiyathad, Nattiya Hirankarn and Pisit Tangkijvanich
ORCID
Author(s) ORCID Number
Apichaya Khlaiphuengsin http://orcid.org/0000-0001-5797-5747
Natthaya Chuaypen http://orcid.org/0000-0002-5415-510X
Pimpayao Sodsai http://orcid.org/0000-0003-0368-9416
Supranee Buranapraditkun http://orcid.org/0000-0001-9971-4318
Tadech Boonpiyathad http://orcid.org/0000-0001-8690-7647
Nattiya Hirankarn http://orcid.org/0000-0003-2224-6856
Pisit Tangkijvanich http://orcid.org/0000-0002-2926-8671
Funding Agency and Grant Number
Funding Agency Grant Number
The Thailand Research Fund RTA6280004
The Grant for Chula Research Scholar CU-GRS-61-07-30-02
Second Century Fund (C2F), Chulalongkorn University
Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University
Corresponding author Pisit Tangkijvanich, MD, Doctor, Professor, Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Pathumwan, Bangkok 10330, Thailand. pisittkvn@yahoo.com
Keywords B cells; Hepatitis B virus; Hepatocellular carcinoma; B cell-activating factor receptor; ;
Core Tip This study explored the expression of B cell-activating factor receptor (BAFF-R) and B cell subpopulations in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Our data showed that BAFF-R expression was significantly lower in patient with HCC compared with non-HCC and healthy controls. In addition, the frequencies of CD27+IgD+ memory B cells, CD27+IgD- class-switched memory B cells and plasmablasts were significantly lower in the patients with HCC compared to patients without HCC. In addition, decreased BAFF-R expression was significantly correlated with tumor size and tumor stage. This study is the first report suggesting that the depletion of BAFF-R in B cells might be responsible for B cell maturation in patients with HBV-related HCC.
Publish Date 2020-05-28 13:08
Citation Khlaiphuengsin A, Chuaypen N, Sodsai P, Buranapraditkun S, Boonpiyathad T, Hirankarn N, Tangkijvanich P. Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2020; 26(20): 2645-2656
Url https://www.wjgnet.com/1007-9327/full/v26/i20/2645.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i20.2645
Full Article (PDF) WJG-26-2645.pdf
Full Article (Word) WJG-26-2645.docx
Manuscript File 54114-Review.docx
Answering Reviewers 54114-Answering reviewers.pdf
Audio Core Tip 54114-Audio core tip.m4a
Biostatistics Review Certificate 54114-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54114-Conflict-of-interest statement.pdf
Copyright License Agreement 54114-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54114-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 54114-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 54114-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 54114-Language certificate.pdf
Supplementary Material 54114-Supplementary material.pdf
Peer-review Report 54114-Peer-review(s).pdf
Scientific Misconduct Check 54114-Scientific misconduct check.pdf
Scientific Editor Work List 54114-Scientific editor work list.pdf