BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/14/2020 1:45:26 PM | Browse: 97 | Download: 59
Publication Name World Journal of Gastroenterology
Manuscript ID 54350
Country/Territory China
Received
2020-01-21 20:22
Peer-Review Started
2020-01-21 20:22
To Make the First Decision
Return for Revision
2020-02-27 03:51
Revised
2020-03-26 12:26
Second Decision
2020-05-12 10:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-12 21:36
Articles in Press
2020-05-12 21:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-16 09:28
Typeset the Manuscript
2020-06-12 08:54
Publish the Manuscript Online
2020-06-14 13:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Optimal dosing time of Dachengqi decoction for protection of extrapancreatic organs in rats with experimental acute pancreatitis
Manuscript Source Unsolicited Manuscript
All Author List Jia-Qi Yao, Lin Zhu, Yi-Fan Miao, Lv Zhu, Huan Chen, Ling Yuan, Jing Hu, Xiao-Lin Yi, Qiu-Ting Wu, Xi-Jing Yang, Mei-Hua Wan and Wen-Fu Tang
ORCID
Author(s) ORCID Number
Jia-Qi Yao http://orcid.org/0000-0002-7822-910X
Lin Zhu http://orcid.org/0000-0001-9126-5722
Yi-Fan Miao http://orcid.org/0000-0002-3483-2345
Lv Zhu http://orcid.org/0000-0002-4302-3339
Huan Chen http://orcid.org/0000-0002-4763-6730
Ling Yuan http://orcid.org/0000-0002-0921-713X
Jing Hu http://orcid.org/0000-0002-8952-0357
Xiao-Lin Yi http://orcid.org/0000-0003-0872-1155
Qiu-Ting Wu http://orcid.org/0000-0002-6282-5791
Xi-Jing Yang http://orcid.org/0000-0001-8451-2000
Mei-Hua Wan http://orcid.org/0000-0002-1237-9455
Wen-Fu Tang http://orcid.org/0000-0001-9294-6634
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81603480
National Natural Science Foundation of China 81573857
Corresponding author Wen-Fu Tang, PhD, Professor, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. tangwf@scu.edu.cn
Key Words The oral administration time; Dachengqi decoction; Pharmacokinetics; Pharmacodynamics; Acute pancreatitis; Extrapancreatic organs
Core Tip This study is the first to assess the optimal dosing time of Dachengqi decoction for protecting the extrapancreatic organs of acute pancreatitis rats. Based on the pharmacokinetic and pharmacodynamic experiments, we proved that delayed administration may be more appropriate in alleviating damage to multiple extrapancreatic organs in acute pancreatitis rats. In addition, this is the first time we have tried to compare the efficacy at different times after administration, and we found that a single-dose administration of the decoction leads to a rapid onset of relief but no steady-state effect, suggesting that multiple-dose administration should be considered.
Publish Date 2020-06-14 13:45
Citation Yao JQ, Zhu L, Miao YF, Zhu L, Chen H, Yuan L, Hu J, Yi XL, Wu QT, Yang XJ, Wan MH, Tang WF. Optimal dosing time of Dachengqi decoction for protection of extrapancreatic organs in rats with experimental acute pancreatitis. World J Gastroenterol 2020; 26(22): 3056-3075
Url https://www.wjgnet.com/1007-9327/full/v26/i22/3056.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i22.3056
Full Article (PDF) WJG-26-3056.pdf
Full Article (Word) WJG-26-3056.docx
Manuscript File 54350-Review_WangTQ.docx
Answering Reviewers 54350-Answering reviewers.pdf
Audio Core Tip 54350-Audio core tip.m4a
Biostatistics Review Certificate 54350-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54350-Conflict-of-interest statement.pdf
Copyright License Agreement 54350-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54350-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 54350-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 54350-Language certificate.pdf
Supplementary Material 54350-Supplementary material.pdf
Peer-review Report 54350-Peer-review(s).pdf
Scientific Misconduct Check 54350-CrossCheck.png
Scientific Misconduct Check 54350-Scientific misconduct check.pdf
Scientific Editor Work List 54350-Scientific editor work list.pdf