ISSN |
1948-0210 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Orthopedics |
Manuscript Type |
Review |
Article Title |
Insights of stem cell-based endogenous repair of intervertebral disc degeneration
|
Manuscript Source |
Invited Manuscript |
All Author List |
Yang Liu, Yan Li, Li-Ping Nan, Feng Wang, Shi-Feng Zhou, Xin-Min Feng, Hao Liu and Liang Zhang |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81972136 |
National Natural Science Foundation for Young Scholars of China |
81401830 |
Guangxi Natural Science Foundation General Project |
2018JJA14775 |
Young Medical Scholars Major Program of Jiangsu Province |
QNRC2016342 |
Innovation Team Project of Jiangsu Province |
CXTDB2017004 |
Key Funding Project of Maternal and Child Health Research of Jiangsu Province |
F201801 |
|
Corresponding Author |
Liang Zhang, MD, PhD, Academic Research, Assistant Professor, Associate Chief Physician, Chief Doctor, Research Scientist, Surgeon, Department of Orthopedics, Clinical Medical College of Yangzhou University, No. 98, Nantong West Road, Yangzhou 225000, Jiangsu Province, China. zhangliang6320@sina.com |
Key Words |
Low back pain; Intervertebral disc degeneration; Stem cell niche; Stem/progenitor cell; Endogenous repair strategy; Stem cell treatment |
Core Tip |
Low back pain has become more prevalent and brought enormous economic burden in recent years. However, therapies including conservative treatment, surgery and cell-based treatment still have several defects. Endogenous repair is a novel therapeutic strategy of intervertebral disc degenerative disease that draws increased attention. We review the research regarding endogenous repair strategy which using stem/progenitor cells as main cell resource, concluding and analyzing the status at present and perspective of endogenous repair strategy in future. |
Publish Date |
2020-04-27 02:55 |
Citation |
Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Feng XM, Liu H, Zhang L. Insights of stem cell-based endogenous repair of intervertebral disc degeneration. World J Stem Cells 2020; 12(4): 266-276 |
URL |
https://www.wjgnet.com/ 1948-0210/full/v12/i4/266.htm |
DOI |
https://dx.doi.org/ 10.4252/wjsc.v12.i4.266 |