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7/28/2020 2:46:56 PM | Browse: 17 | Download: 12
Publication Name World Journal of Gastroenterology
Manuscript ID 54484
Country/Territory Germany
Received
2020-02-03 23:49
Peer-Review Started
2020-02-03 23:49
To Make the First Decision
Return for Revision
2020-02-27 03:16
Revised
2020-05-24 22:06
Second Decision
2020-06-17 09:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-17 20:53
Articles in Press
2020-06-17 20:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-07 03:30
Typeset the Manuscript
2020-07-28 07:31
Publish the Manuscript Online
2020-07-28 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease
Manuscript Source Invited Manuscript
All Author List Friederike Cordes, Dirk Foell, John Nik Ding, Georg Varga and Dominik Bettenworth
ORCID
Author(s) ORCID Number
Friederike Cordes http://orcid.org/0000-0002-0376-0764
Dirk Foell http://orcid.org/0000-0002-1946-3916
John Nik Ding http://orcid.org/0000-0002-6232-1948
Georg Varga http://orcid.org/0000-0002-1547-8766
Dominik Bettenworth http://orcid.org/0000-0002-1435-4825
Funding Agency and Grant Number
Corresponding author Friederike Cordes, MD, Doctor, Department of Medicine B for Gastroenterology and Hepatology, University Hospital Münster, Albert-Schweitzer-Campus 1, Münster D-48149, Germany. annafriederike.cordes@ukmuenster.de
Keywords Janus kinase; Signal transducer and activator of transcription; JAK/STAT pathway; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; JAK/STAT inhibition; Tofacitinib
Core Tip The pan-Janus kinase (JAK)-inhibitor tofacitinib is efficacious in patients with active ulcerative colitis (UC) but not Crohn’s disease (CD), which hints at different contribution of JAK-signaling in both entities. In this review available data on differential JAK/signal transducer and activator of transcription (STAT)-signaling in UC and CD were analyzed. Literature review identified differential cell-subset specific JAK/STAT-signaling including increased T-cell-associated STAT1 signaling in CD and STAT6 signaling in UC, while in myeloid cells inflammatory STAT1 was increased in UC compared with CD indicating a less inflammatory role of myeloid cells in CD. Development of JAK/STAT-inhibitors with specific targeting of associated inflammatory pathways might further improve efficacy and safety profiles of this drug class.
Publish Date 2020-07-28 14:46
Citation Cordes F, Foell D, Ding JN, Varga G, Bettenworth D. Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease. World J Gastroenterol 2020; 26(28): 4055-4075
Url https://www.wjgnet.com/1007-9327/full/v26/i28/4055.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i28.4055
Full Article (PDF) WJG-26-4055.pdf
Full Article (Word) WJG-26-4055.docx
Manuscript File 54484-Review-Webster J.docx
Answering Reviewers 54484-Answering reviewers.pdf
Audio Core Tip 54484-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 54484-Conflict-of-interest statement.pdf
Copyright License Agreement 54484-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 54484-Language certificate.pdf
Peer-review Report 54484-Peer-review(s).pdf
Scientific Misconduct Check 54484-Scientific misconduct check.pdf
Scientific Editor Work List 54484-Scientific editor work list.pdf