| Category |
Medicine, General & Internal |
| Manuscript Type |
Topic Highlights |
| Article Title |
Circadian clock circuitry in colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Gianluigi Mazzoccoli, Manlio Vinciguerra, Gennaro Papa and Ada Piepoli |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Italian Ministry of Health through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy |
RC1203ME46 (to GM) |
| Italian Ministry of Health through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy |
RC1302ME31 (to GM) |
| Italian Ministry of Health through Department of Medical Sciences, Division of Gastroenterology and Research Laboratory |
RC1203GA55 |
| Italian Ministry of Health through Department of Medical Sciences, Division of Gastroenterology and Research Laboratory |
RC1203GA56 |
| AIRC |
MFAG-AIRC2012-13419 (to MV) |
|
| Corresponding Author |
Gianluigi Mazzoccoli, MD, Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, Cappuccini Avenue, 71013 San Giovanni Rotondo Foggia, Italy. g.mazzoccoli@operapadrepio.it |
| Key Words |
Colorectal cancer; Circadian rhythm; Clock gene |
| Core Tip |
The biological clock drives crucial cell processes, such as growth, proliferation, differentiation and apoptosis, controls metabolic pathways, and regulates tissue functions and behavioral cycles. Derangement of these phenomena is involved in colorectal carcinogenesis. The circadian clock circuitry is a leading actor in physiological regulation, a drawn in bystander in colorectal tumorigenesis, and a possible therapeutic target. |
| Publish Date |
2014-04-17 13:27 |
| Citation |
Mazzoccoli G, Vinciguerra M, Papa G, Piepoli A. Circadian clock circuitry in colorectal cancer. World J Gastroenterol 2014; 20(15): 4197-4207 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i15/4197.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i15.4197 |
