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Publication Name World Journal of Stem Cells
Manuscript ID 54987
Country/Territory China
2020-02-28 08:53
Peer-Review Started
2020-02-28 08:59
To Make the First Decision
Return for Revision
2020-04-02 20:44
2020-04-10 09:18
Second Decision
2020-07-21 09:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-26 21:13
Articles in Press
2020-07-26 21:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-03 02:37
Typeset the Manuscript
2020-08-13 12:49
Publish the Manuscript Online
2020-08-26 05:49
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Review
Article Title Stem cell therapy for Alzheimer's disease
Manuscript Source Invited Manuscript
All Author List Xin-Yu Liu, Lin-Po Yang and Lan Zhao
Author(s) ORCID Number
Xin-Yu Liu http://orcid.org/0000-0002-1520-4159
Lin-Po Yang http://orcid.org/0000-0002-2814-8520
Lan Zhao http://orcid.org/0000-0002-7449-2947
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81202740
Tianjin Natural Science Fund 17JCYBJC26200
Corresponding Author Lan Zhao, PhD, Research Fellow, Tianjin Institution of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Chang Ling Road, Xi Qing District, Tianjin 300381, China. lanzhao69@163.com
Key Words Alzheimer's disease; Stem cell; Therapy; Pathogenesis; Animal experiment; Clinical trial
Core Tip Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.
Publish Date 2020-08-26 05:49
Citation Liu XY, Yang LP, Zhao L. Stem cell therapy for Alzheimer's disease. World J Stem Cells 2020; 12(8): 787-802
Url https://www.wjgnet.com/1948-0210/full/v12/i8/787.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i8.787
Full Article (PDF) WJSC-12-787.pdf
Full Article (Word) WJSC-12-787.docx
Manuscript File 54987-Review_WangTQ.docx
Answering Reviewers 54987-Answering reviewers.pdf
Audio Core Tip 54987-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 54987-Conflict-of-interest statement.pdf
Copyright License Agreement 54987-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54987-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54987-Language certificate.pdf
Peer-review Report 54987-Peer-review(s).pdf
Scientific Misconduct Check 54987-Scientific misconduct check.pdf
Scientific Editor Work List 54987-Scientific editor work list.pdf