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12/18/2020 12:27:09 PM | Browse: 528 | Download: 871
Publication Name World Journal of Clinical Oncology
Manuscript ID 55011
Country/Territory Spain
Received
2020-03-21 19:33
Peer-Review Started
2020-03-21 19:34
To Make the First Decision
Return for Revision
2020-09-24 20:08
Revised
2020-09-28 12:53
Second Decision
2020-10-21 12:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-10-21 16:50
Articles in Press
2020-10-21 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-10-27 01:42
Typeset the Manuscript
2020-12-16 06:55
Publish the Manuscript Online
2020-12-18 12:27
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Hematology
Manuscript Type Minireviews
Article Title Predictive indicators of successful tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia
Manuscript Source Invited Manuscript
All Author List Ruth Stuckey, Juan Francisco López-Rodríguez, Santiago Sánchez-Sosa, Adrián Segura-Díaz, Nuria Sanchéz-Farías, Cristina Bilbao-Sieyro and María Teresa Gómez-Casares
ORCID
Author(s) ORCID Number
Ruth Stuckey http://orcid.org/0000-0001-6955-2290
Juan Francisco López-Rodríguez http://orcid.org/0000-0002-4862-4088
Santiago Sánchez-Sosa http://orcid.org/0000-0002-7211-8003
Adrián Segura-Díaz http://orcid.org/0000-0002-2070-3227
Nuria Sanchéz-Farías http://orcid.org/0000-0003-1819-589X
Cristina Bilbao-Sieyro http://orcid.org/0000-0002-4796-1445
María Teresa Gómez-Casares http://orcid.org/0000-0003-0505-5126
Funding Agency and Grant Number
Corresponding Author María Teresa Gómez-Casares, MD, PhD, Chief Doctor, Department of Hematology, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de la Ballena s/n, Las Palmas de Gran Canaria 35019, Las Palmas de Gran Canaria, Spain. mgomcasf@gobiernodecanarias.org
Key Words Biomarkers; Tyrosine kinase inhibitors; Treatment discontinuation; Molecular monitoring; Duration of therapy; Leukemia; Myelogenous; Chronic; BCR-ABL positive
Core Tip Clinical trials have shown that approximately 50% of patients with chronic myeloid leukemia who reach a deep molecular response (MR) following treatment for several years with tyrosine kinase inhibitors (TKI) can discontinue and remain in treatment-free remission (TFR). Factors such as the duration of TKI treatment and duration and depth of the patient’s MR prior to discontinuation appear to be important in determining whether TFR is achieved. However, it is clear that other biological factors must determine whether an individual will remain in TFR after discontinuation. Future studies should aim to elucidate biomarkers predictive of TFR.
Publish Date 2020-12-18 12:27
Citation Stuckey R, López-Rodríguez JF, Sánchez-Sosa S, Segura-Díaz A, Sánchez-Farías N, Bilbao-Sieyro C, Gomez-Casares MT. Predictive indicators of successful tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia. World J Clin Oncol 2020; 11(12): 996-1007
URL https://www.wjgnet.com/2218-4333/full/v11/i12/996.htm
DOI https://dx.doi.org/10.5306/wjco.v11.i12.996
Full Article (PDF) WJCO-11-996.pdf
Full Article (Word) WJCO-11-996.docx
Manuscript File 55011-Review-Filipodia.docx
Answering Reviewers 55011-Answering reviewers.pdf
Audio Core Tip 55011-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 55011-Conflict-of-interest statement.pdf
Copyright License Agreement 55011-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 55011-Language certificate.pdf
Peer-review Report 55011-Peer-review(s).pdf
Scientific Misconduct Check 55011-Bing-Fan JR-2.png
Scientific Misconduct Check 55011-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 55011-Scientific misconduct check.pdf
Scientific Editor Work List 55011-Scientific editor work list.pdf