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Publication Name World Journal of Gastroenterology
Manuscript ID 55044
Country/Territory Spain
Received
2020-02-28 11:13
Peer-Review Started
2020-02-28 11:13
To Make the First Decision
Return for Revision
2020-04-09 16:09
Revised
2020-05-08 16:48
Second Decision
2020-05-18 10:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-18 17:45
Articles in Press
2020-05-18 17:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-05-27 04:45
Publish the Manuscript Online
2020-05-28 13:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Conservation and variability of hepatitis B core at different chronic hepatitis stages
Manuscript Source Invited Manuscript
All Author List Marçal Yll, Maria Francesca Cortese, Mercedes Guerrero-Murillo, Gerard Orriols, Josep Gregori, Rosario Casillas, Carolina González, Sara Sopena, Cristina Godoy, Marta Vila, David Tabernero, Josep Quer, Ariadna Rando, Rosa López-Martinez, Rafael Esteban, Mar Riveiro-Barciela, Maria Buti and Francisco Rodriguez-Frias
ORCID
Author(s) ORCID Number
Marçal Yll http://orcid.org/0000-0002 -7030-3360
Maria Francesca Cortese http://orcid.org/0000-0002-4318-532X
Mercedes Guerrero-Murillo http://orcid.org/0000-0002-5556-2460
Gerard Orriols http://orcid.org/0000-0002-1138-5909
Josep Gregori http://orcid.org/0000-0002-4253-8015
Rosario Casillas http://orcid.org/0000-0002-6758-6734
Carolina González http://orcid.org/0000-0002-0169-5874
Sara Sopena http://orcid.org/0000-0002-3309-5486
Cristina Godoy http://orcid.org/0000-0001-5037-1916
Marta Vila http://orcid.org/0000-0001-9303-5189
David Tabernero http://orcid.org/0000-0002-1146-4084
Josep Quer http://orcid.org/0000-0003-0014-084X
Ariadna Rando http://orcid.org/0000-0003-4555-7286
Rosa López-Martinez http://orcid.org/0000-0002-8450-6986
Rafael Esteban http://orcid.org/0000-0001-5280-392X
Mar Riveiro-Barciela http://orcid.org/0000-0001-9309-2052
Maria Buti http://orcid.org/0000-0002-0732-3078
Francisco Rodriguez-Frias http://orcid.org/0000-0001-9058-4641
Funding Agency and Grant Number
Funding Agency Grant Number
Instituto de Salud Carlos III PI18/01436
European Regional Development Fund (ERDF)
Corresponding Author Maria Francesca Cortese, MSc, PhD, Postdoc, Research Scientist, Liver Pathology Unit, Departments of Biochemistry and Microbiology. Liver Unit, Liver Disease Laboratory-Viral Hepatitis, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona. Vall d'Hebron Institut Recerca-Hospital Universitari Vall d'Hebron, Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain. maria.cortese@vhir.org
Key Words Hepatitis B virus; Hepatitis B core gene; Next-generation sequencing; Genetic conservation; Amino acid substitution; Gene therapy
Core Tip New tools for hepatitis B virus infection treatment and follow-up are needed. Hepatitis B virus core protein has a key role in viral replication and persistence. Analysis of viral quasispecies by next-generation sequencing can identify conserved regions in viral genes or proteins that may serve as targets for new therapeutic and diagnostic strategies. Moreover, it may help identify prognostic markers of liver disease progression. Here, we detected hyper-conserved nucleotide and amino acid regions regardless of the clinical stage. Moreover, we observed several group-specific conserved and variable regions and an amino acid substitution that could be indicative of different disease progression.
Publish Date 2020-05-28 13:08
Citation Yll M, Cortese MF, Guerrero-Murillo M, Orriols G, Gregori J, Casillas R, González C, Sopena S, Godoy C, Vila M, Tabernero D, Quer J, Rando A, Lopez-Martinez R, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F. Conservation and variability of hepatitis B core at different chronic hepatitis stages. World J Gastroenterol 2020; 26(20): 2584-2598
Url https://www.wjgnet.com/1007-9327/full/v26/i20/2584.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i20.2584
Full Article (PDF) WJG-26-2584.pdf
Full Article (Word) WJG-26-2584.docx
Manuscript File 55044-Review.docx
Answering Reviewers 55044-Answering reviewers.pdf
Audio Core Tip 55044-Audio core tip.mp3
Biostatistics Review Certificate 55044-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 55044-Conflict-of-interest statement.pdf
Copyright License Agreement 55044-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 55044-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 55044-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 55044-Language certificate.pdf
Supplementary Material 55044-Supplementary material.pdf
Peer-review Report 55044-Peer-review(s).pdf
Scientific Misconduct Check 55044-Bing-Tang JZ-1.png
Scientific Misconduct Check 55044-Scientific misconduct check.pdf
Scientific Editor Work List 55044-Scientific editor work list.pdf