ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Virology |
Manuscript Type |
Basic Study |
Article Title |
Conservation and variability of hepatitis B core at different chronic hepatitis stages
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Manuscript Source |
Invited Manuscript |
All Author List |
Marçal Yll, Maria Francesca Cortese, Mercedes Guerrero-Murillo, Gerard Orriols, Josep Gregori, Rosario Casillas, Carolina González, Sara Sopena, Cristina Godoy, Marta Vila, David Tabernero, Josep Quer, Ariadna Rando, Rosa López-Martinez, Rafael Esteban, Mar Riveiro-Barciela, Maria Buti and Francisco Rodriguez-Frias |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Instituto de Salud Carlos III |
PI18/01436 |
European Regional Development Fund (ERDF) |
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Corresponding Author |
Maria Francesca Cortese, MSc, PhD, Postdoc, Research Scientist, Liver Pathology Unit, Departments of Biochemistry and Microbiology. Liver Unit, Liver Disease Laboratory-Viral Hepatitis, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona. Vall d'Hebron Institut Recerca-Hospital Universitari Vall d'Hebron, Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain. maria.cortese@vhir.org |
Key Words |
Hepatitis B virus; Hepatitis B core gene; Next-generation sequencing; Genetic conservation; Amino acid substitution; Gene therapy |
Core Tip |
New tools for hepatitis B virus infection treatment and follow-up are needed. Hepatitis B virus core protein has a key role in viral replication and persistence. Analysis of viral quasispecies by next-generation sequencing can identify conserved regions in viral genes or proteins that may serve as targets for new therapeutic and diagnostic strategies. Moreover, it may help identify prognostic markers of liver disease progression. Here, we detected hyper-conserved nucleotide and amino acid regions regardless of the clinical stage. Moreover, we observed several group-specific conserved and variable regions and an amino acid substitution that could be indicative of different disease progression. |
Publish Date |
2020-05-28 13:08 |
Citation |
Yll M, Cortese MF, Guerrero-Murillo M, Orriols G, Gregori J, Casillas R, González C, Sopena S, Godoy C, Vila M, Tabernero D, Quer J, Rando A, Lopez-Martinez R, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F. Conservation and variability of hepatitis B core at different chronic hepatitis stages. World J Gastroenterol 2020; 26(20): 2584-2598 |
URL |
https://www.wjgnet.com/1007-9327/full/v26/i20/2584.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v26.i20.2584 |