ISSN |
2220-3206 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Psychiatry |
Manuscript Type |
Basic Study |
Article Title |
Serum levels of chemokines in adolescents with major depression treated with fluoxetine
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Manuscript Source |
Invited Manuscript |
All Author List |
Francisco Rafael de la Peña, Carlos Cruz-Fuentes, Lino Palacios, Manuel Iván Girón-Pérez, Emilio Medina-Rivero, Maria Dolores Ponce-Regalado, Samantha Alvarez-Herrera, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, José Luis Maldonado-García, María C Jiménez-Martínez and Lenin Pavón |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Secretaria de Ciencia, Tecnología e Innovación |
0048/2014 |
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Corresponding Author |
Lenin Pavón, PhD, Professor, Laboratory of Psychoimmunology, National Institute of Psychiatry, “Ramón de la Fuente”, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Mexico City 14070, Mexico. lkuriaki@imp.edu.mx |
Key Words |
Adolescents; Major depression; Chemokine; Fluoxetine; Interferon gamma-induced protein-10; |
Core Tip |
Major depressive disorder affects 350 million of persons, approximately 6% of them are adolescents. This study aimed to determine the differences in circulatory levels of chemokines like eotaxin, interleukin-8, induced protein 10, monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1α and MIP-1β in healthy volunteers and adolescents with major depression and assess the changes induced by antidepressants consume during 8 wk of clinical follow-up, which is the minimum time to observe the therapeutic efficacy of selective serotonin reuptake inhibitors, like fluoxetine in adolescents. Our results showed a significant elevation in serum chemokine levels in adolescents with major depression despite treatment with fluoxetine and an improvement in scores of Hamilton depresión rating scale. |
Publish Date |
2020-08-13 05:58 |
Citation |
de la Peña FR, Cruz-Fuentes C, Palacios L, Girón-Pérez MI, Medina-Rivero E, Ponce-Regalado MD, Alvarez-Herrera S, Pérez-Sánchez G, Becerril-Villanueva E, Maldonado-García JL, Jiménez-Martínez MDC, Pavón L. Serum levels of chemokines in adolescents with major depression treated with fluoxetine. World J Psychiatr 2020; 10(8): 175-186 |
URL |
https://www.wjgnet.com/2220-3206/full/v10/i8/175.htm |
DOI |
https://dx.doi.org/10.5498/wjp.v10.i8.175 |