| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Dong Wen, Fang Lu, Ying-Pan Zhao, Ping Wang, Qian Yang, Jun-Xiang Li, Hui-Zhen Li, Li-Li Chi, Zheng-Hua Zhou, Yan-Ping Tang, Jin-Kang Xu, Yang Zhao and Xu-Dong Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National New Drug Innovation Program |
2017ZX09304003 |
| Special Research on Modernization of Traditional Chinese Medicine in the National Key Research and Development Program in the 13th Five-Year Plan Demonstrative Research |
2017YFC1703703 |
|
| Corresponding Author |
Xu-Dong Tang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuancaochang, Haidian District, Beijing 100091, China. txdly@sina.com |
| Key Words |
Biling Weitong Granules; Compound formula; Traditional Chinese medicine; Functional dyspepsia; Epigastric pain syndrome; Randomized controlled trial |
| Core Tip |
Although the currently available drugs for functional dyspepsia (FD) can, to some extent, improve the symptoms, they are still ineffective or have severe adverse reactions in some patients. The present study evaluated the clinical efficacy and safety of Biling Weitong Granules in treating epigastric pain syndrome in FD patients. Compared with placebo, Biling Weitong Granules markedly relieved the epigastric pain syndrome symptoms and significantly improved the total FD clinical score based on symptoms including postprandial fullness and discomfort, early satiety, epigastric pain, epigastric burning, belching, and pharyngeal obstruction, decreased appetite, fatigue, limb weakness, and irritability, thus, it improved the quality of life without causing serious adverse reactions. |
| Publish Date |
2020-07-28 14:46 |
| Citation |
Wen YD, Lu F, Zhao YP, Wang P, Yang Q, Li JX, Li HZ, Chi LL, Zhou ZH, Tang YP, Xu JK, Zhao Y, Tang XD. Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules. World J Gastroenterol 2020; 26(28): 4170-4181 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i28/4170.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i28.4170 |
