BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/26/2020 12:01:04 PM | Browse: 722 | Download: 1005
Publication Name World Journal of Stem Cells
Manuscript ID 55683
Country/Territory Germany
Received
2020-03-28 17:02
Peer-Review Started
2020-03-28 17:02
To Make the First Decision
Return for Revision
2020-04-22 16:11
Revised
2020-05-03 20:13
Second Decision
2020-08-24 12:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-25 05:29
Articles in Press
2020-08-25 05:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-09-10 05:59
Typeset the Manuscript
2020-10-18 09:16
Publish the Manuscript Online
2020-10-26 12:01
ISSN 1948-0210 (online)
Open Access Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Basic Study
Article Title In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts
Manuscript Source Invited Manuscript
All Author List Fabrice F Darche, Rasmus Rivinius, Ann-Kathrin Rahm, Eva Köllensperger, Uwe Leimer, Günter Germann, Miriam Reiss, Michael Koenen, Hugo A Katus, Dierk Thomas and Patrick A Schweizer
ORCID
Author(s) ORCID Number
Fabrice F Darche http://orcid.org/0000-0003-4896-9219
Rasmus Rivinius http://orcid.org/0000-0003-1146-6319
Ann-Kathrin Rahm http://orcid.org/0000-0002-7509-887X
Eva Köllensperger http://orcid.org/0000-0003-0813-5797
Uwe Leimer http://orcid.org/0000-0003-4438-8134
Günter Germann http://orcid.org/0000-0002-9526-2024
Miriam Reiss http://orcid.org/0000-0001-6575-5779
Michael Koenen http://orcid.org/0000-0002-2737-258X
Hugo A Katus http://orcid.org/0000-0002-2293-2314
Dierk Thomas http://orcid.org/0000-0002-5687-7843
Patrick A Schweizer http://orcid.org/0000-0002-7212-1202
Funding Agency and Grant Number
Funding Agency Grant Number
Max-Planck-Society (TANDEM project to Koenen M and Schweizer PA)
Ministry of Science, Research and the Arts Baden-Wuerttemberg (Sonderlinie Medizin to Thomas D)
German Heart Foundation (Kaltenbach scholarship to Darche FF)
German Cardiac Society (Otto-Hess scholarship to Rahm AK)
Heidelberg Medical Faculty (Physician Scientist-Programm to Darche FF, Rivinius R and Rahm AK)
German Cardiac Society (Research scholarship to Rivinius R)
the German Society of Internal Medicine (Clinician-Scientist-Program to Rahm AK)
the German Centre for Cardiovascular Research (DZHK)
Corresponding Author Patrick A Schweizer, MD, Associate Professor, Senior Scientist, Department of Cardiology, University of Heidelberg, INF 410, Heidelberg D-69120, Germany. patrick.schweizer@med.uni-heidelberg.de
Key Words Biological cardiac pacemaker; Mesenchymal stem cells; Differentiation; Animal model; Cell transplantation; Stem cell therapy
Core Tip Differentiated human mesenchymal stem cells from adipose tissue (dhaMSC) transplanted into the myocardium of domestic pigs are able to generate a biological pacemaker system in vivo. Electrocardiogram recordings and immunohistochemical analyses of pigs with transplanted dhaMSC indicated successful biological pacemaker generation. Preconditioning of cells was achieved by in vitro treatment of human mesenchymal stem cells in differentiation culture medium. Due to their reduced immunoreactivity, xenogeneic transplantation of human MSC into pig hearts was feasible without immunosuppression. dhaMSC maintained their immunoprivileged status over time.
Publish Date 2020-10-26 12:01
Citation Darche FF, Rivinius R, Rahm AK, Köllensperger E, Leimer U, Germann G, Reiss M, Koenen M, Katus HA, Thomas D, Schweizer PA. In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts. World J Stem Cells 2020; 12(10): 1133-1151
URL https://www.wjgnet.com/1948-0210/full/v12/i10/1133.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i10.1133
Full Article (PDF) WJSC-12-1133.pdf
Full Article (Word) WJSC-12-1133.docx
Manuscript File 55683-Review-Webster J.doc
Answering Reviewers 55683-Answering reviewers.pdf
Audio Core Tip 55683-Audio core tip.m4a
Biostatistics Review Certificate 55683-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 55683-Conflict-of-interest statement.pdf
Copyright License Agreement 55683-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 55683-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 55683-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 55683-Institutional review board statement.pdf
Peer-review Report 55683-Peer-review(s).pdf
Scientific Misconduct Check 55683-Scientific misconduct check.pdf
Scientific Editor Work List 55683-Scientific editor work list.pdf