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Publication Name World Journal of Gastroenterology
Manuscript ID 56190
Country China
2020-04-23 06:05
Peer-Review Started
2020-04-23 06:05
To Make the First Decision
Return for Revision
2020-05-01 02:22
2020-07-27 12:16
Second Decision
2020-08-11 12:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-12 07:24
Articles in Press
2020-08-12 07:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-23 19:09
Typeset the Manuscript
2020-09-09 01:10
Publish the Manuscript Online
2020-09-17 01:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations
Manuscript Source Unsolicited Manuscript
All Author List Bi-Xia Huang, Yan Liu, Zhen-Ping Fan, Lan-Lan Si, Rong-Juan Chen, Jun Wang, Dan Luo, Fu-Sheng Wang, Dong-Ping Xu and Xin-Guang Liu
Author(s) ORCID Number
Bi-Xia Huang http://orcid.org/0000-0002-4469-0467
Yan Liu http://orcid.org/0000-0003-1498-4314
Zhen-Ping Fan http://orcid.org/0000-0001-9761-3337
Lan-Lan Si http://orcid.org/0000-0003-0222-5169
Rong-Juan Chen http://orcid.org/0000-0001-8090-1682
Jun Wang http://orcid.org/0000-0002-6261-8995
Dan Luo http://orcid.org/0000-0002-1889-2882
Fu-Sheng Wang http://orcid.org/0000-0002-8043-6685
Dong-Ping Xu http://orcid.org/0000-0002-0754-4620
Xin-Guang Liu http://orcid.org/0000-0001-6963-1386
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81572010
the National Natural Science Foundation of China 81671399
the National Natural Science Foundation of China 81721002
the National Natural Science Foundation of China 81971329
the Capital Health Research and Development of Special Fund Program 2016-2-5032
Beijing Natural Science Foundation 7172206
Corresponding Author Dong-Ping Xu, MD, PhD, Professor, Institute of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, 100, Xisihuan Middle Road, Beijing 100039, China. xudongping302@sina.com
Key Words Hepatitis B virus; Immune escape-associated mutation; Drug-resistance mutation; Nucleoside/nucleotide analogs; Hepatitis B surface antigen; The major hydrophilic region
Core Tip A large number of patients were surveyed for immune escape-associated mutations, and the link between immune escape-associated and resistant mutations was identified. Contribution of sA159V to resistance was found in multiple followed-up patients, especially sA159V reduced hepatitis B surface antigen but raised replication capacity of lamivudine/entecavir-resistant mutants.
Publish Date 2020-09-17 01:56
Citation Huang BX, Liu Y, Fan ZP, Si LL, Chen RJ, Wang J, Luo D, Wang FS, Xu DP, Liu XG. Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations. World J Gastroenterol 2020; 26(35): 5314-5327
URL https://www.wjgnet.com/1007-9327/full/v26/i35/5314.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i35.5314
Full Article (PDF) WJG-26-5314.pdf
Full Article (Word) WJG-26-5314.docx
Manuscript File 56190-Review-Filipodia.docx
Answering Reviewers 56190-Answering reviewers.pdf
Audio Core Tip 56190-Audio core tip.m4a
Biostatistics Review Certificate 56190-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 56190-Conflict-of-interest statement.pdf
Copyright License Agreement 56190-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56190-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 56190-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 56190-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 56190-Language certificate.pdf
Peer-review Report 56190-Peer-review(s).pdf
Scientific Misconduct Check 56190-Bing-Yan JP-1.png
Scientific Misconduct Check 56190-Scientific misconduct check.pdf
Scientific Editor Work List 56190-Scientific editor work list.pdf