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12/18/2020 5:58:43 AM | Browse: 624 | Download: 1106
Publication Name World Journal of Hepatology
Manuscript ID 56366
Country/Territory France
Received
2020-06-11 15:05
Peer-Review Started
2020-06-11 15:05
To Make the First Decision
Return for Revision
2020-09-18 16:52
Revised
2020-10-07 15:21
Second Decision
2020-10-28 10:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-10-28 18:03
Articles in Press
2020-10-28 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-01 21:48
Typeset the Manuscript
2020-12-02 01:32
Publish the Manuscript Online
2020-12-18 05:58
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Prospective Study
Article Title Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus
Manuscript Source Invited Manuscript
All Author List Anaïs Brayette, Marie Essig, Paul Carrier, Marilyne Debette-Gratien, Anaïs Labrunie, Sophie Alain, Marianne Maynard, Nathalie Ganne-Carrié, Eric Nguyen-Khac, Pauline Pinet, Victor De Ledinghen, Christophe Renou, Philippe Mathurin, Claire Vanlemmens, Vincent Di Martino, Anne Gervais, Juliette Foucher, Fouchard-Hubert Isabelle, Julien Vergniol, Isabelle Hourmand-Ollivier, Daniel Cohen, Xavier Duval, Thierry Poynard, Marc Bardou, Armand Abergel, Manh-Thong Dao, Thierry Thévenot, Jean-Baptiste Hiriart, Valérie Canva, Guillaume Lassailly, Christine Aurières, Nathalie Boyer, Dominique Thabut, Pierre-Henri Bernard, Matthieu Schnee, Dominique Larrey, Bertrand Hanslik, Séverine Hommel, Jérémie Jacques and Véronique Loustaud-Ratti
ORCID
Author(s) ORCID Number
Anaïs Brayette http://orcid.org/0000-0003-2253-8111
Marie Essig http://orcid.org/0000-0002-2030-5616
Paul Carrier http://orcid.org/0000-0001-9750-2506
Marilyne Debette-Gratien http://orcid.org/0000-0001-6039-1355
Anaïs Labrunie http://orcid.org/0000-0002-3285-8015
Sophie Alain http://orcid.org/0000-0002-9787-1421
Marianne Maynard http://orcid.org/0000-0001-9172-7050
Nathalie Ganne-Carrié http://orcid.org/0000-0002-7351-5027
Eric Nguyen-Khac http://orcid.org/0000-0001-8672-4146
Pauline Pinet http://orcid.org/0000-0001-9259-6857
Victor De Ledinghen http://orcid.org/0000-0001-6414-1951
Christophe Renou http://orcid.org/0000-0002-5834-2391
Philippe Mathurin http://orcid.org/0000-0003-3447-2025
Claire Vanlemmens http://orcid.org/0000-0002-2048-3324
Vincent Di Martino http://orcid.org/0000-0002-2022-690X
Anne Gervais http://orcid.org/0000-0001-8593-6083
Juliette Foucher http://orcid.org/0000-0003-2712-7469
Fouchard-Hubert Isabelle http://orcid.org/0000-0002-7420-7026
Julien Vergniol http://orcid.org/0000-0002-1109-1636
Isabelle Hourmand-Ollivier http://orcid.org/0000-0002-5254-2464
Daniel Cohen http://orcid.org/0000-0001-7461-6375
Xavier Duval http://orcid.org/0000-0003-1079-4230
Thierry Poynard http://orcid.org/0000-0002-2050-640X
Marc Bardou http://orcid.org/0000-0003-0028-1837
Armand Abergel http://orcid.org/0000-0001-7480-1052
Manh-Thong Dao http://orcid.org/0000-0001-7043-4662
Thierry Thévenot http://orcid.org/0000-0003-3974-2784
Jean-Baptiste Hiriart http://orcid.org/0000-0002-8863-8230
Valérie Canva http://orcid.org/0000-0003-4364-8133
Guillaume Lassailly http://orcid.org/0000-0002-6955-244X
Christine Aurières http://orcid.org/0000-0003-4732-104X
Nathalie Boyer http://orcid.org/0000-0003-1873-1701
Dominique Thabut http://orcid.org/0000-0002-9658-0323
Pierre-Henri Bernard http://orcid.org/0000-0003-0154-0722
Matthieu Schnee http://orcid.org/0000-0001-6152-405X
Dominique Larrey http://orcid.org/0000-0002-0892-3489
Bertrand Hanslik http://orcid.org/0000-0002-1803-0799
Séverine Hommel http://orcid.org/0000-0001-7335-4772
Jérémie Jacques http://orcid.org/0000-0003-4105-6804
Véronique Loustaud-Ratti http://orcid.org/0000-0002-6951-0784
Funding Agency and Grant Number
Funding Agency Grant Number
Bristol Myers Squibb, France
Corresponding Author Véronique Loustaud-Ratti, MD, PhD, Professor, U1248 INSERM, Department of Hepatology and Gastroenterology, Univ. Limoges, CHU Limoges, 2, Avenue Martin Luther King,, Limoges F-87000, France. veronique.loustaud-ratti@unilim.fr
Key Words Hepatitis B virus; Proximal tubulopathy; Biomarkers; Renal insufficiency; Nucleoside analogues;
Core Tip The objective of this prospective, multicenter study was to determine the 24 mo prevalence and incidence of subclinical proximal tubulopathy (SPT) in hepatitis B virus (HBV)-monoinfected patients that were either treatment-naïve or treated with nucleot(s)ide analogues. Data on early SPT markers, the estimated glomerular filtration rate, and phosphatemia were collected quarterly from 196 patients. The prevalence and incidence of SPT was higher in tenofovir disoproxil-treated patients compared to naïve patients. The median survival time without SPT (time during which more than 50% of the patients remained SPT-free), evaluated only in the tenofovir disoproxil-treated group, was 5.9 mo. SPT was detected in the naïve population, indicating possible HBV-induced toxicity in renal tubules.
Publish Date 2020-12-18 05:58
Citation Brayette A, Essig M, Carrier P, Debette-Gratien M, Labrunie A, Alain S, Maynard M, Ganne-Carrié N, Nguyen-Khac E, Pinet P, De Ledinghen V, Renou C, Mathurin P, Vanlemmens C, Di Martino V, Gervais A, Foucher J, Isabelle FH, Vergniol J, Hourmand-Ollivier I, Cohen D, Duval X, Poynard T, Bardou M, Abergel A, Dao MT, Thévenot T, Hiriart JB, Canva V, Lassailly G, Aurières C, Boyer N, Thabut D, Bernard PH, Schnee M, Larrey D, Hanslik B, Hommel S, Jacques J, Loustaud-Ratti V. Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus. World J Hepatol 2020; 12(12): 1326-1340
URL https://www.wjgnet.com/1948-5182/full/v12/i12/1326.htm
DOI https://dx.doi.org/10.4254/wjh.v12.i12.1326
Full Article (PDF) WJH-12-1326.pdf
Full Article (Word) WJH-12-1326.docx
Manuscript File 56366-Review-Filipodia.docx
Answering Reviewers 56366-Answering reviewers.pdf
Audio Core Tip 56366-Audio core tip.mp3
Biostatistics Review Certificate 56366-Biostatistics statement.pdf
Clinical Trial Registration Statement 56366-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 56366-Conflict-of-interest statement.pdf
Copyright License Agreement 56366-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56366-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 56366-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 56366-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 56366-Language certificate.pdf
Peer-review Report 56366-Peer-review(s).pdf
Scientific Misconduct Check 56366-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 56366-Bing-Fan JR-2.png
Scientific Misconduct Check 56366-Scientific misconduct check.pdf
Scientific Editor Work List 56366-Scientific editor work list.pdf