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Articles Published Processes
8/28/2020 3:06:40 PM | Browse: 562 | Download: 1027
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Received |
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2020-05-07 03:00 |
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Peer-Review Started |
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2020-05-07 03:01 |
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To Make the First Decision |
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Return for Revision |
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2020-05-21 21:24 |
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Revised |
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2020-06-04 13:53 |
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Second Decision |
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2020-08-03 06:03 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-08-03 23:03 |
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Articles in Press |
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2020-08-03 23:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-08-10 07:01 |
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Typeset the Manuscript |
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2020-08-27 00:26 |
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Publish the Manuscript Online |
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2020-08-28 15:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Dual targeting of Polo-like kinase 1 and baculoviral inhibitor of apoptosis repeat-containing 5 in TP53-mutated hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Li, Zhen-Gang Zhao, Yin Luo, Hao Cui, Hao-Yu Wang, Yan-Fang Jia and Ying-Tang Gao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Major Project |
2018ZX10732-202-004 |
| Tianjin Science and Technology Plan Project |
17JCYBJC26100 |
| Tianjin Science and Technology Plan Project |
19ZXDBSY00030 |
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| Corresponding Author |
Ying-Tang Gao, PhD, Professor, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Center Hospital, No. 83, Jintang Road, Hedong District, Tianjin 300170, China. gaoyt816@163.com |
| Key Words |
Polo-like kinase 1; Baculoviral inhibitor of apoptosis repeat-containing 5; p53; Co-expression; Hepatocellular carcinoma; Bioinformatics analysis |
| Core Tip |
A bioinformatics analysis using a TCGA hepatocellular carcinoma (HCC) dataset revealed that Polo-like kinase 1 (PLK1) and baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) were overexpressed in the same patient subset and their expression was highly correlated. Overexpression of both PLK1 and BIRC5 was more frequently detected in HCC with p53 mutations. High PLK1 or BIRC5 expression significantly correlated with poor clinical outcome. The PLK1 inhibitors volasertib and GSK461364 or BIRC5 inhibitor YM155 selectively targeted Huh7 cells with mutated p53, but not HepG2 cells with wild-type p53. Combination treatment with volasertib and YM155 synergistically inhibited the viability of Huh7 cells by inducing apoptosis. The efficacies of volasertib and YM155 alone or in combination were validated in vivo in Huh7-derived xenograft model in immuno-deficient NSIG mice. |
| Publish Date |
2020-08-28 15:06 |
| Citation |
Li Y, Zhao ZG, Luo Y, Cui H, Wang HY, Jia YF, Gao YT. Dual targeting of Polo-like kinase 1 and baculoviral inhibitor of apoptosis repeat-containing 5 in TP53-mutated hepatocellular carcinoma. World J Gastroenterol 2020; 26(32): 4786-4801 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i32/4786.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i32.4786 |
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