Publication Name	World Journal of Gastroenterology
Manuscript ID	5663
Country	Greece

Received	2013-09-20 11:09
Peer-Review Started	2013-09-21 20:00
To Make the First Decision	2013-10-14 21:26
Return for Revision	2013-10-20 18:45
Revised	2013-10-29 19:37
Second Decision	2014-01-06 18:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-06 19:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-11 11:21
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies
Manuscript Source	Invited Manuscript
All Author List	Theodore Lytras, Georgios Nikolopoulos and Stefanos Bonovas
Funding Agency and Grant Number
Corresponding Author	Theodore Lytras, MD, MPH, Department of Occupational and Industrial Hygiene, National School of Public Health, 196 Alexandras Ave., 11521 Athens, Greece. thlytras@gmail.com
Key Words	3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; Statins; Colorectal cancer; Systematic review; Meta-analysis; Cancer chemoprevention
Core Tip	To investigate the association between statin use and colorectal cancer risk, we conducted a systematic review and meta-analysis of published studies. A total of 40 studies, involving more than eight million subjects, contributed to our analysis. A modest reduction in the risk of colorectal cancer with statin use was observed, which was not statistically significant among RCTs (RR = 0.89, 95%CI: 0.74-1.07; n = 8), but reached statistical significance among cohort studies (RR = 0.91, 95%CI: 0.83-1.00; n = 13) and case-control studies (RR = 0.92, 95%CI: 0.87-0.98; n = 19). Further targeted research is warranted.
Publish Date	2014-03-12 11:24
Citation	Lytras T, Nikolopoulos G, Bonovas S. Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies. World J Gastroenterol 2014; 20(7): 1858-1870
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1858.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1858

Full Article (PDF)	WJG-20-1858.pdf
Full Article (Word)	WJG-20-1858.doc
Manuscript File	5663-Review.doc
Answering Reviewers	5663-Answering reviewers.pdf
Copyright License Agreement	5663-Copyright assignment.pdf
Peer-review Report	5663-Peer reviewer(s).pdf
Scientific Editor Work List	5663-Scientific editor work list.doc