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1/6/2021 7:32:42 AM | Browse: 381 | Download: 814
Publication Name World Journal of Critical Care Medicine
Manuscript ID 57287
Country/Territory India
Received
2020-06-02 14:42
Peer-Review Started
2020-06-02 14:43
To Make the First Decision
Return for Revision
2020-07-04 21:53
Revised
2020-11-11 12:48
Second Decision
2020-11-25 11:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-29 22:27
Articles in Press
2020-11-29 22:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-12-10 00:51
Typeset the Manuscript
2020-12-28 00:58
Publish the Manuscript Online
2021-01-06 07:32
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Prospective Study
Article Title Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (cytoSorb®) in patients with sepsis and septic shock
Manuscript Source Unsolicited Manuscript
All Author List Rajib Paul, Prachee Sathe, Senthil Kumar, Shiva Prasad, Ma Aleem and Prashant Sakhalvalkar
ORCID
Author(s) ORCID Number
Rajib Paul http://orcid.org/0000-0002-5691-1191
Prachee Sathe http://orcid.org/0000-0002-1236-1669
Senthil Kumar http://orcid.org/0000-0001-9339-988X
Shiva Prasad http://orcid.org/0000-0001-6254-1919
Ma Aleem http://orcid.org/0000-0002-8080-7466
Prashant Sakhalvalkar http://orcid.org/0000-0001-5691-1506
Funding Agency and Grant Number
Corresponding Author Rajib Paul, DNB, MD, Doctor, Professor, Department of Internal Medicine and Critical Care, Apollo Health City, Road Number 72, opp, Bharatiya Vidya Bhavan School, Jubilee Hills, Hyderabad 500033, India. rajib.paulcriticalcare@gmail.com
Key Words Acute physiology and chronic health evaluation score; Hemadsorption; Sepsis; Sequential organ failure assessment score; Vasopressor
Core Tip This prospective, real time, observational multicenter study was conducted in 45 patients with sepsis and septic shock. Post therapy, 26 patients survived and dose reduction in norepinephrine, epinephrine and vasopressin was 51.4%, 69.4% and 13.9%, respectively. Interleukin-6 levels reduction was 52.3% and platelet count improved significantly to 30.1%. Mean acute physiology and chronic health evaluation and sequential organ failure assessment scores reduced significantly. Predicted mortality before CytoSorb® therapy was 56.5% that reduced to 48.8% after CytoSorb® therapy. The survival rate in patients given treatment in < 24 h of intensive care unit admission was 75% and 68% when given within 24-48 h of intensive care unit admission. CytoSorb® therapy was safe and well tolerated with no adverse events reported.
Publish Date 2021-01-06 07:32
Citation Paul R, Sathe P, Kumar RS, Prasad S, Aleem M, Sakhalvalkar P. Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (cytoSorb®) in patients with sepsis and septic shock. World J Crit Care Med 2021; 10(1): 22-34
URL https://www.wjgnet.com/2220-3141/full/v10/i1/22.htm
DOI https://dx.doi.org/10.5492/wjccm.v10.i1.22
Full Article (PDF) WJCCM-10-22.pdf
Full Article (Word) WJCCM-10-22.docx
Manuscript File 57287-Review-Filipodia.docx
Answering Reviewers 57287-Answering reviewers.pdf
Audio Core Tip 57287-Audio core tip.mp4
Biostatistics Review Certificate 57287-Biostatistics statement.pdf
Clinical Trial Registration Statement 57287-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 57287-Conflict-of-interest statement.pdf
Copyright License Agreement 57287-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 57287-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 57287-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 57287-Language certificate.pdf
Peer-review Report 57287-Peer-review(s).pdf
Scientific Misconduct Check 57287-Bing-Yan JP-1.png
Scientific Misconduct Check 57287-Scientific misconduct check.pdf
Scientific Editor Work List 57287-Scientific editor work list.pdf