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9/2/2014 3:20:00 PM | Browse: 927 | Download: 661
Publication Name World Journal of Gastroenterology
Manuscript ID 5753
Country/Territory Italy
Received
2013-09-25 10:29
Peer-Review Started
2013-09-25 16:21
To Make the First Decision
2013-11-21 21:00
Return for Revision
2013-11-22 08:56
Revised
2013-12-03 18:58
Second Decision
2014-01-15 20:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-15 20:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-19 11:58
Publish the Manuscript Online
2014-02-26 11:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Telomeres, telomerase and colorectal cancer
Manuscript Source Invited Manuscript
All Author List Roberta Bertorelle, Enrica Rampazzo, Salvatore Pucciarelli, Donato Nitti and Anita De Rossi
Funding Agency and Grant Number
Corresponding Author Anita De Rossi, PhD, Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy. anita.derossi@unipd.it
Key Words Telomere; Telomerase; Telomerase reverse transcriptase; Colorectal cancer; Prognostic marker
Core Tip Telomere/telomerase interplay is an important mechanism involved in both genomic stability and cellular replicative potential. Telomere shortening is an early event that contributes to genetic instability, which plays a key role in the early steps of carcinogenesis. The activation of telomerase, which preserves replicative potential by maintaining the length of telomeres, occurs during the adenoma-carcinoma sequence and increases during tumour progression. While the prognostic value of telomere length is controversial, most studies agree that the level of telomerase in tumours represents a useful prognostic marker. Circulating telomerase reverse transcriptase is a promising marker for the minimally invasive monitoring of disease and response to therapy.
Publish Date 2014-02-26 11:18
Citation Bertorelle R, Rampazzo E, Pucciarelli S, Nitti D, De Rossi A. Telomeres, telomerase and colorectal cancer. World J Gastroenterol 2014; 20(8): 1940-1950
URL http://www.wjgnet.com/1007-9327/full/v20/i8/1940.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i8.1940
Full Article (PDF) WJG-20-1940.pdf
Full Article (Word) WJG-20-1940.doc
Manuscript File 5753-Review.docx
Answering Reviewers 5753-Answering reviewers.pdf
Copyright License Agreement 5753-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 5753-Language certificate.pdf
Peer-review Report 5753-Peer reviews.pdf
Scientific Editor Work List 5753-Scientific editor work list.doc