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9/1/2014 5:04:00 PM | Browse: 1057 | Download: 912
Publication Name World Journal of Gastroenterology
Manuscript ID 5767
Country/Territory Poland
Received
2013-09-25 13:19
Peer-Review Started
2013-09-25 16:51
To Make the First Decision
2013-11-21 20:59
Return for Revision
2013-11-22 09:22
Revised
2013-12-10 02:50
Second Decision
2014-01-15 20:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-15 20:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-05 09:43
Publish the Manuscript Online
2014-03-12 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Sex hormones in the modulation of irritable bowel syndrome
Manuscript Source Invited Manuscript
All Author List Agata Mulak, Yvette Taché and Muriel Larauche
Funding Agency and Grant Number
Funding Agency Grant Number
Veterans Administration Research Career Scientist Award to Taché Y
National Institute of Health P50 DK-64539 (to Taché Y)
National Institute of Health K01-DK088937 (to Larauche M)
Corresponding Author Agata Mulak, MD, PhD, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. agata.mulak@wp.pl
Key Words Brain-gut axis; Irritable bowel syndrome; Microbiota; Pain modulation; Sex hormones
Core Tip Recent clinical and experimental findings support the modulatory actions of sex hormones exerted at different levels of the brain-gut-microbiota axis in irritable bowel syndrome (IBS). Sex hormones may influence peripheral and central regulatory mechanisms contributing to the alterations in visceral sensitivity, motility, permeability, and immune activation of intestinal mucosa. A new concept of “microgenderome” is emerging based on the observations that the gender bias present in numerous diseases may be reinforced by the commensal microbiota of the host. Significant sex differences in epidemiology, symptomatology, and treatment outcome in IBS indicate the necessity for sex-tailored therapeutic approach in this disorder.
Publish Date 2014-03-12 14:46
Citation Mulak A, Taché Y, Larauche M. Sex hormones in the modulation of irritable bowel syndrome. World J Gastroenterol 2014; 20(10): 2433-2448
URL http://www.wjgnet.com/1007-9327/full/v20/i10/2433.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i10.2433
Full Article (PDF) WJG-20-2433.pdf
Full Article (Word) WJG-20-2433.doc
Manuscript File 5767-Review.doc
Answering Reviewers 5767-Answering reviewers.pdf
Copyright License Agreement 5767-Copyright assignment.pdf
Peer-review Report 5767-Peer reviews.pdf
Scientific Editor Work List 5767-Scientific editor work list.doc