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11/18/2020 2:20:37 PM | Browse: 16 | Download: 16
Publication Name World Journal of Clinical Oncology
Manuscript ID 57785
Country/Territory Spain
Received
2020-06-23 13:19
Peer-Review Started
2020-06-23 13:20
To Make the First Decision
Return for Revision
2020-07-25 20:33
Revised
2020-07-30 00:55
Second Decision
2020-10-12 10:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-10-12 22:16
Articles in Press
2020-10-12 22:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-10-18 20:31
Typeset the Manuscript
2020-11-08 15:00
Publish the Manuscript Online
2020-11-18 14:20
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Deep diving in the PACIFIC: Practical issues in stage III non-small-cell lung cancer to avoid shipwreck
Manuscript Source Invited Manuscript
All Author List Xabier Mielgo-Rubio, Federico Rojo, Laura Mezquita-Pérez, Francesc Casas, Amadeo Wals, Manel Juan, Carlos Aguado, Javier Garde-Noguera, David Vicente and Felipe Couñago
ORCID
Author(s) ORCID Number
Xabier Mielgo-Rubio http://orcid.org/0000-0002-0985-6150
Federico Rojo http://orcid.org/0000-0001-9989-0290
Laura Mezquita-Pérez http://orcid.org/0000-0003-0936-7338
Francesc Casas http://orcid.org/0000-0001-6464-0603
Amadeo Wals http://orcid.org/0000-0002-8869-1015
Manel Juan http://orcid.org/0000-0002-3064-1648
Carlos Aguado http://orcid.org/0000-0002-5624-8035
Javier Garde-Noguera http://orcid.org/0000-0001-7043-067X
David Vicente http://orcid.org/0000-0002-6052-0070
Felipe Couñago http://orcid.org/0000-0001-7233-0234
Funding Agency and Grant Number
Corresponding Author Xabier Mielgo-Rubio, MD, Staff Physician, Department of Medical Oncology, Hospital Universitario Fundación Alcorcón, Calle Budapest 1, Alcorcón, Madrid 28922, Spain. xmielgo@hotmail.com
Key Words Durvalumab; Non-small-cell lung cancer; PACIFIC; Immunotherapy; Immune checkpoint inhibitors; Anti-programmed cell death ligand 1
Core Tip Durvalumab consolidation therapy is the new standard of care in patients with unresectable stage III non-small cell lung cancer treated with concomitant chemoradiotherapy. In the PACIFIC trial, durvalumab significantly improved both progression-free and overall survival compared to placebo, with a manageable toxicity profile. However, several questions surrounding the clinical implementation of this therapy remain, including optimal patient selection and timing of treatment initiation, programmed cell death ligand 1 (PD-L1) determination, and the impact on clinical routines. These questions make interdisciplinary decision-making more necessary than ever. This review assesses these issues and future challenges from a multidisciplinary approach.
Publish Date 2020-11-18 14:20
Citation Mielgo-Rubio X, Rojo F, Mezquita-Pérez L, Casas F, Wals A, Juan M, Aguado C, Garde-Noguera J, Vicente D, Couñago F. Deep diving in the PACIFIC: Practical issues in stage III non-small-cell lung cancer to avoid shipwreck. World J Clin Oncol 2020; 11(11): 898-917
Url https://www.wjgnet.com/2218-4333/full/v11/i11/898.htm
DOI https://dx.doi.org/10.5306/wjco.v11.i11.898
Full Article (PDF) WJCO-11-898.pdf
Full Article (Word) WJCO-11-898.docx
Manuscript File 57785-Review-Filipodiav1.docx
Answering Reviewers 57785-Answering reviewers.pdf
Audio Core Tip 57785-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 57785-Conflict-of-interest statement.pdf
Copyright License Agreement 57785-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 57785-Language certificate.pdf
Peer-review Report 57785-Peer-review(s).pdf
Scientific Misconduct Check 57785-Scientific misconduct check.pdf
Scientific Editor Work List 57785-Scientific editor work list.pdf