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8/29/2014 11:31:00 AM | Browse: 995 | Download: 966
Publication Name World Journal of Gastroenterology
Manuscript ID 5784
Country/Territory South Korea
Received
2013-09-25 22:14
Peer-Review Started
2013-09-27 08:30
To Make the First Decision
2014-01-09 15:45
Return for Revision
2014-01-20 09:21
Revised
2014-01-30 13:46
Second Decision
2014-02-20 15:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-20 16:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-04-11 10:16
Publish the Manuscript Online
2014-04-17 13:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer
Manuscript Source Invited Manuscript
All Author List Jung Ho Kim and Gyeong Hoon Kang
Funding Agency and Grant Number
Funding Agency Grant Number
National R&D Program for Cancer Control funded by the Ministry of Health and Welfare, South Korea 0720540
National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) 2011-0030768
Priority Research Centers Program through the NRF grant funded by the Ministry of Education, Science and Technology (MEST), South Korea 2009-0093820
Mid-career Researcher Program through the NRF grant funded by MEST 2011-0015646
Corresponding Author Gyeong Hoon Kang, MD, PhD, Professor, Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. ghkang@snu.ac.kr
Key Words Colorectal cancer; Microsatellite instability; DNA mismatch repair; DNA methylation; CpG islands; Prognosis; Adjuvant chemotherapy
Core Tip A high level of microsatellite instability (MSI-H) is a known molecular indicator of a favorable prognosis and low benefit of 5-fluorouracil-based adjuvant chemotherapy in patients with colorectal cancer (CRC). However, MSI-H CRCs are molecularly heterogeneous tumors, which are characterized by DNA mismatch repair deficiency and various genetic and epigenetic alterations. Therefore, we hypothesized that MSI-H CRCs can be divided into prognostic subgroups based on the molecular heterogeneity. This article provides an up-to-date review concerning the underlying molecular features of MSI-H CRCs and potential prognostic or predictive molecular markers for MSI-H CRCs.
Publish Date 2014-04-17 13:27
Citation Kim JH, Kang GH. Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer. World J Gastroenterol 2014; 20(15): 4230-4243
URL http://www.wjgnet.com/1007-9327/full/v20/i15/4230.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i15.4230
Full Article (PDF) WJG-20-4230.pdf
Full Article (Word) WJG-20-4230.doc
Manuscript File 5784-Review.doc
Answering Reviewers 5784-Answering reviewers.pdf
Copyright License Agreement 5784-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 5784-Language certificate.pdf
Peer-review Report 5784-Peer reviews.pdf
Scientific Editor Work List 5784-Scientific editor work list.doc