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1/7/2021 8:35:07 AM | Browse: 454 | Download: 595
Publication Name World Journal of Diabetes
Manuscript ID 58148
Country/Territory China
Received
2020-08-21 08:57
Peer-Review Started
2020-08-16 07:55
To Make the First Decision
Return for Revision
2020-09-21 17:14
Revised
2020-10-05 14:00
Second Decision
2020-10-26 14:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-10-26 18:04
Articles in Press
2020-10-26 18:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-17 14:11
Typeset the Manuscript
2021-01-06 07:06
Publish the Manuscript Online
2021-01-07 08:35
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop
Manuscript Source Unsolicited Manuscript
All Author List Yang Zhou, Xiao-Yu Ma, Jin-Yu Han, Min Yang, Chuan Lv, Ying Shao, Yi-Li Wang, Jia-Yi Kang and Qiu-Yue Wang
ORCID
Author(s) ORCID Number
Yang Zhou http://orcid.org/0000-0001-7587-6996
Xiao-Yu Ma http://orcid.org/0000-0002-7374-7370
Jin-Yu Han http://orcid.org/0000-0001-8548-0127
Min Yang http://orcid.org/0000-0001-7734-8281
Chuan Lv http://orcid.org/0000-0001-8410-3688
Ying Shao http://orcid.org/0000-0002-3929-3459
Yi-Li Wang http://orcid.org/0000-0002-9412-5933
Jia-Yi Kang http://orcid.org/0000-0002-2216-8117
Qiu-Yue Wang http://orcid.org/0000-0002-2242-3122
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Research and Development Program of China 2018YFC1313901
The Higher School Highend Talent Team Construction of Liaoning Province [2014]187
Corresponding Author Qiu-Yue Wang, PhD, Professor, Department of Endocrinology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110000, Liaoning Province, China. wqycmu123@163.com
Key Words Tenascin-C; miR-155-5p; Metformin; Type 2 diabetes mellitus; Diabetic kidney disease; Toll-like receptor 4
Core Tip Investigate the correlation between serum tenascin-C (TNC) levels and urine albumin clearance ratios in a total of 380 patients with type 2 diabetes mellitus, TNC can regulates mir-155-5p through Toll-like receptor 4/nuclear factor κB signaling in rat mesangial cells under hyperglycaemia condition, metformin can inhibit inflammation and fibrosis in diabetic kidney disease through TNC.
Publish Date 2021-01-07 08:35
Citation Zhou Y, Ma XY, Han JY, Yang M, Lv C, Shao Y, Wang YL, Kang JY, Wang QY. Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop. World J Diabetes 2021; 12(1): 19-46
URL https://www.wjgnet.com/1948-9358/full/v12/i1/19.htm
DOI https://dx.doi.org/10.4239/wjd.v12.i1.19
Full Article (PDF) WJD-12-19.pdf
Full Article (Word) WJD-12-19.docx
Manuscript File 58148_Auto_Edited_WangTQ.docx
Answering Reviewers 58148-Answering reviewers.pdf
Audio Core Tip 58148-Audio core tip.wma
Biostatistics Review Certificate 58148-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 58148-Conflict-of-interest statement.pdf
Copyright License Agreement 58148-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 58148-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 58148-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 58148-Institutional review board statement.pdf
Peer-review Report 58148-Peer-review(s).pdf
Scientific Misconduct Check 58148-Scientific misconduct check.pdf
Scientific Editor Work List 58148-Scientific editor work list.pdf