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3/20/2021 2:13:53 AM | Browse: 479 | Download: 1205
Publication Name World Journal of Hepatology
Manuscript ID 58278
Country/Territory Spain
Received
2020-08-14 16:41
Peer-Review Started
2020-08-14 16:42
To Make the First Decision
Return for Revision
2020-12-11 19:05
Revised
2020-12-27 16:12
Second Decision
2021-03-11 13:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-12 00:55
Articles in Press
2021-03-12 00:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-03-18 01:51
Publish the Manuscript Online
2021-03-20 02:13
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Retrospective Study
Article Title Early tacrolimus exposure does not impact long-term outcomes after liver transplantation
Manuscript Source Unsolicited Manuscript
All Author List Mikel Gastaca, Patricia Ruiz, Javier Bustamante, Lorea Martinez-Indart, Alberto Ventoso, José Ramón Fernandez, Ibone Palomares, Mikel Prieto, Milagros Testillano, Patricia Salvador, Maria Senosiain, Maria Jesus Suárez and Andres Valdivieso
ORCID
Author(s) ORCID Number
Mikel Gastaca http://orcid.org/0000-0003-2771-9640
Patricia Ruiz http://orcid.org/0000-0002-2598-0370
Javier Bustamante http://orcid.org/0000-0002-5280-3038
Lorea Martinez-Indart http://orcid.org/0000-0003-3241-6345
Alberto Ventoso http://orcid.org/0000-0003-4635-8545
José Ramón Fernandez http://orcid.org/0000-0002-9746-2812
Ibone Palomares http://orcid.org/0000-0002-0002-7436
Mikel Prieto http://orcid.org/0000-0001-6662-4252
Milagros Testillano http://orcid.org/0000-0001-7917-1862
Patricia Salvador http://orcid.org/0000-0001-7741-9465
Maria Senosiain http://orcid.org/0000-0001-7595-7059
Maria Jesus Suárez http://orcid.org/0000-0002-9827-2914
Andres Valdivieso http://orcid.org/0000-0002-2614-3670
Funding Agency and Grant Number
Corresponding Author Mikel Gastaca, MD, Associate Professor, Surgeon, Department of HPB Surgery and Liver Transplantation Unit, Hospital Universitario Cruces, PLaza de Cruces s/n, Bilbao 48903, Spain. mikelgastaca@gmail.com
Key Words Liver transplantation; Tacrolimus levels; Prolonged released tacrolimus; Once-daily tacrolimus; Renal function; Survival; Outcomes
Core Tip This is a retrospective study to evaluate the effect of early tacrolimus trough levels (TTL) on the long-term outcomes after liver transplantation. Patients were classified into 2 groups according to mean TTL within the first month: ≤ 10 (n = 98) and > 10 ng/mL (n = 57). After a median follow-up of 52.8 mo (range 2.8-81.1), no significant differences were observed in: Mean estimated glomerular filtration rate, hepatocellular carcinoma recurrence, de novo tumors, biopsy-proven acute rejection rate and five-year patient and graft survival. Differences in tacrolimus levels within the first month after liver transplant did not result in significant differences in long-term outcomes.
Publish Date 2021-03-20 02:13
Citation Gastaca M, Ruiz P, Bustamante J, Martinez-Indart L, Ventoso A, Fernandez JR, Palomares I, Prieto M, Testillano M, Salvador P, Senosiain M, Suárez MJ, Valdivieso A. Early tacrolimus exposure does not impact long-term outcomes after liver transplantation. World J Hepatol 2021; 13(3): 362-374
URL https://www.wjgnet.com/1948-5182/full/v13/i3/362.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i3.362
Full Article (PDF) WJH-13-362.pdf
Full Article (Word) WJH-13-362.docx
Manuscript File 58278_Auto_Edited.docx
Answering Reviewers 58278-Answering reviewers.pdf
Audio Core Tip 58278-Audio core tip.m4a
Biostatistics Review Certificate 58278-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 58278-Conflict-of-interest statement.pdf
Copyright License Agreement 58278-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 58278-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 58278-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 58278-Language certificate.pdf
Peer-review Report 58278-Peer-review(s).pdf
Scientific Misconduct Check 58278-Bing-Huang P-1.png
Scientific Misconduct Check 58278-Bing-Fan JR-2.png
Scientific Misconduct Check 58278-Scientific misconduct check.pdf
Scientific Editor Work List 58278-Scientific editor work list.pdf