Publication Name	World Journal of Gastroenterology
Manuscript ID	5846
Country	South Korea

Received	2013-09-28 15:37
Peer-Review Started	2013-09-29 13:46
To Make the First Decision	2013-11-21 20:59
Return for Revision	2013-11-22 09:30
Revised	2013-12-01 14:35
Second Decision	2014-02-20 15:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-20 16:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-03 10:44
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Irritable bowel syndrome: Emerging paradigm in pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Yoo Jin Lee and Kyung Sik Park
Funding Agency and Grant Number
Corresponding Author	Kyung Sik Park, Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 700-712, South Korea. seenae99@dsmc.or.kr
Key Words	Pathophysiology; Irritable bowel syndrome; Inflammation; Immunologic; Genetics; Microbiota; Diet; Enteroendocrine cell
Core Tip	In recent years, several novel mechanisms of irritable bowel syndrome (IBS) that likely relate to previously established IBS theories have been identified. Inflammation and postinfectious low-grade inflammation are emerging areas requiring clarification with regard to IBS pathophysiology. Immunological and genetic predisposition along with altered microbiota are critical in IBS development, while several dietary factors and enteroendocrine cells may also play roles in this syndrome. However, none of these accounts for the full repertoire of IBS symptoms, and the pathophysiology of this condition is not fully understood.
Publish Date	2014-03-12 14:46
Citation	Lee YJ, Park KS. Irritable bowel syndrome: Emerging paradigm in pathophysiology. World J Gastroenterol 2014; 20(10): 2456-2469
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2456.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2456

Full Article (PDF)	WJG-20-2456.pdf
Full Article (Word)	WJG-20-2456.doc
Manuscript File	5846-Review.docx
Answering Reviewers	5846-Answering reviewers.pdf
Copyright License Agreement	5846-Copyright assignment.pdf
Peer-review Report	5846-Peer reviews.pdf
Scientific Editor Work List	5846-Scientific editor work list.doc