| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Luigi E Adinolfi, Rosa Zampino, Luciano Restivo, Amedeo Lonardo, Barbara Guerrera, Aldo Marrone, Fabio Nascimbeni, Anna Florio and Paola Loria |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Regione Campania, Italy |
|
|
| Corresponding Author |
Luigi E Adinolfi, MD, Professor, Director of Internal Medicine, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Marcianise (CE), 80100 Naples, Italy. luigielio.adinolfi@unina2.it
|
| Key Words |
Hepatitis C virus; Atherosclerosis; Coronary artery disease; Stroke; Inflammation |
| Core Tip |
Hepatitis C virus (HCV) infection represents a risk factor for carotid atherosclerosis, heart failure and ischemic stroke. However, findings from studies addressing coronary artery disease and HCV have yielded conflicting results. Moreover, an excess of cardiovascular mortality among anti-HCV positive subjects has been reported. HCV promotes atherogenesis through direct and indirect mechanisms. Inflammation, cytokines activation, cellular and humoral immunity, metabolic derangement, oxidative stress, liver steatosis and fibrosis have been postulated as potential atherogenic mechanisms. Knowledge of such complex mechanisms may be important for understanding disease progression and promoting novel therapeutic approaches. At present, interferon-based treatment of chronic hepatitis C seems to reduce the risk of stroke as well as non-liver-related mortality.
|
| Publish Date |
2014-04-04 15:11 |
| Citation |
Adinolfi LE, Zampino R, Restivo L, Lonardo A, Guerrera B, Marrone A, Nascimbeni F, Florio A, Loria P. Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms. World J Gastroenterol 2014; 20(13): 3410-3417 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i13/3410.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i13.3410 |
