Publication Name	World Journal of Gastroenterology
Manuscript ID	5884
Country	China

Received	2013-09-28 18:22
Peer-Review Started	2013-09-29 15:20
To Make the First Decision	2013-12-26 10:53
Return for Revision	2014-01-17 09:12
Revised	2014-03-21 12:58
Second Decision	2014-04-29 12:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-29 14:21
Articles in Press	2014-05-23 11:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-07 15:00
Typeset the Manuscript	2014-07-07 20:56
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy
Manuscript Source	Invited Manuscript
All Author List	Li-Li Han, Yi Lv, Hui Guo, Zhi-Ping Ruan and Ke-Jun Nan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81172361
Corresponding Author	Ke-Jun Nan, PhD, Department of Medical Oncology, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, No. 58 Chang’an North Road, Beilin District, Xi’an 710061, Shaanxi Province, China. nankj@163.com
Key Words	Biomarkers; Pathogenesis; Hepatocellular carcinoma; Targeted therapy; MicroRNAs
Core Tip	Advances made in the prognosis of hepatocellular carcinoma (HCC) in recent years include improvements in clinical diagnosis using biomarkers and the potential of molecular-targeted therapy. The diagnosis, pathogenesis and targeted therapy of HCC should be comprehensively studied. Several biomarkers, including both traditional biomarkers and novel biomarkers, such as microRNAs, are also essential in the pathogenesis of HCC, and represent important new targets for HCC therapy. Ongoing studies and clinical trials suggest that molecular-targeted drugs that target biomarkers and their pathways will be used to treat HCC.
Publish Date	2014-08-18 16:49
Citation	Han LL, Lv Y, Guo H, Ruan ZP, Nan KJ. Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy. World J Gastroenterol 2014; 20(30): 10249-10261
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10249.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10249

Full Article (PDF)	WJG-20-10249.pdf
Full Article (Word)	WJG-20-10249.doc
Manuscript File	5884-Review.docx
Answering Reviewers	5884-Answering reviewers.pdf
Copyright License Agreement	5884-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5884-Language certificate.PDF
Peer-review Report	5884-Peer reviews.pdf
Scientific Editor Work List	5884-Scientific editor work list.pdf