Publication Name	World Journal of Gastroenterology
Manuscript ID	58973
Country	China

Received	2020-08-17 08:33
Peer-Review Started	2020-08-17 08:34
To Make the First Decision
Return for Revision	2020-09-12 06:05
Revised	2020-09-21 10:08
Second Decision	2020-10-10 10:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-10-13 05:12
Articles in Press	2020-10-13 05:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-10-18 20:47
Typeset the Manuscript	2020-12-03 01:26
Publish the Manuscript Online	2020-12-04 06:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Wei, Hui-Fen Wang, Yu Zhang, Yan-Li Zhang, Bing-Yu Niu and Shu-Kun Yao
ORCID	Author(s) ORCID Number Wei Wei http://orcid.org/0000-0002-8388-0423 Hui-Fen Wang http://orcid.org/0000-0002-0899-1473 Yu Zhang http://orcid.org/0000-0003-0764-0599 Yan-Li Zhang http://orcid.org/0000-0003-4609-7330 Bing-Yu Niu http://orcid.org/0000-0003-1829-7909 Shu-Kun Yao http://orcid.org/0000-0002-8512-2589
Funding Agency and Grant Number	Funding Agency Grant Number National Key Technology Support Program during “12th Five-Year Plan” Period of China 2014BAI08B00 Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) Z171100001717008 Project “The role of the gut microbiota and metabolites in the pathogenesis of diarrheal-predominant irritable bowel syndrome” of China-Japan Friendship Hospital 2019-64-K44
Corresponding Author	Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words	Bile acids; Irritable bowel syndrome; Diarrhea; Visceral hypersensitivity; Microbiota; Dysbiosis
Core Tip	This study comprehensively investigated the fecal bile acids (BAs) profile of irritable bowel syndrome with predominant diarrhea (IBS-D) patients and healthy controls, and the correlations between BAs and clinical characteristics as well as the gut microbiota of IBS-D patients. We found that the composition of fecal BAs in IBS-D patients is featured by increased primary BAs and decreased secondary BAs, which was associated with diarrhea and visceral hypersensitivity. The abnormality of BAs might be induced by dysbiosis in IBS-D patients, especially the reduction of genera in the Ruminococcaceae family, which contains the majority of bacteria that are capable of converting primary BAs into secondary BAs.
Publish Date	2020-12-04 06:04
Citation	Wei W, Wang HF, Zhang Y, Zhang YL, Niu BY, Yao SK. Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2020; 26(45): 7153-7172
URL	https://www.wjgnet.com/1007-9327/full/v26/i45/7153.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i45.7153

Full Article (PDF)	WJG-26-7153.pdf
Full Article (Word)	WJG-26-7153.docx
STROBE Statement	58973-STROBE-Statement-revision.pdf
Manuscript File	58973-Review-Filipodia.docx
Answering Reviewers	58973-Answering reviewers.pdf
Audio Core Tip	58973-Audio core tip.mp3
Biostatistics Review Certificate	58973-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	58973-Conflict-of-interest statement.pdf
Copyright License Agreement	58973-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	58973-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	58973-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	58973-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	58973-Language certificate.pdf
Peer-review Report	58973-Peer-review(s).pdf
Scientific Misconduct Check	58973-Bing-Yan JP-1.png
Scientific Misconduct Check	58973-Scientific misconduct check.pdf
Scientific Editor Work List	58973-Scientific editor work list.pdf