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Publication Name World Journal of Gastroenterology
Manuscript ID 5909
Country/Territory Germany
2013-09-28 20:02
Peer-Review Started
2013-09-29 17:08
To Make the First Decision
2013-12-16 17:07
Return for Revision
2013-12-17 15:14
2014-01-06 22:31
Second Decision
2014-03-06 17:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-06 18:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-18 17:24
Publish the Manuscript Online
2014-04-04 15:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Mathematical and Computational Biology
Manuscript Type Topic Highlights
Article Title Computational biology approach to uncover hepatitis C virus helicase operation
Manuscript Source Invited Manuscript
All Author List Holger Flechsig
Funding Agency and Grant Number
Corresponding author Dr. Holger Flechsig, Department of Physical Chemistry, Fritz Haber Institute of the Max Planck Society, Faradayweg 4-6, 14195 Berlin, Germany. flechsig@fhi-berlin.mpg.de
Keywords Hepatitis C virus; Viral replication; Helicase protein; Adenosine-triphosphate-induced operation; Conformational motions; Nucleic acid unzipping; Computational biology; Coarse-grained modelling; Elastic-network model
Core Tip Proteins that are involved in the replication cycle of hepatitis C virus are relevant targets for antiviral therapies. Their dynamical properties, however, cannot be sufficiently studied in experiments yet. Alternatively, owing to the available power of modern computers, the mechanism by which they operate can be investigated in computer experiments using appropriate models. In this regard, considerable progress has now been achieved for the viral helicase protein and the obtained results, in combination with experimental data, have significantly improved our understanding of its activity.
Publish Date 2014-04-04 15:11
Citation Flechsig H. Computational biology approach to uncover hepatitis C virus helicase operation. World J Gastroenterol 2014; 20(13): 3401-3409
Url http://www.wjgnet.com/1007-9327/full/v20/i13/3401.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i13.3401
Full Article (PDF) WJG-20-3401.pdf
Full Article (Word) WJG-20-3401.doc
Manuscript File 5909-Review.docx
Answering Reviewers 5909-Answering reviewers.pdf
Copyright License Agreement 5909-Copyright assignment.pdf
Peer-review Report 5909-Peer reviews.pdf
Scientific Editor Work List 5909-Scientific editor work list.doc