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2/25/2021 3:45:30 PM | Browse: 389 | Download: 852
Publication Name World Journal of Hepatology
Manuscript ID 59138
Country France
Received
2020-08-27 10:35
Peer-Review Started
2020-08-26 15:56
To Make the First Decision
Return for Revision
2020-10-21 18:21
Revised
2020-11-04 12:45
Second Decision
2020-12-30 08:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-12-30 16:08
Articles in Press
2020-12-30 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-02-24 03:27
Publish the Manuscript Online
2021-02-25 15:45
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs
Manuscript Source Invited Manuscript
All Author List Daria Kartasheva-Ebertz, Jesintha Gaston, Loriane Lair-Mehiri, Pierre-Philippe Massault, Olivier Scatton, Jean-Christophe Vaillant, Vladimir Alexei Morozov, Stanislas Pol and Sylvie Lagaye
ORCID
Author(s) ORCID Number
Daria Kartasheva-Ebertz http://orcid.org/0000-0001-9509-0253
Jesintha Gaston http://orcid.org/0000-0003-4716-7409
Loriane Lair-Mehiri http://orcid.org/0000-0003-4428-8272
Pierre-Philippe Massault http://orcid.org/0000-0002-4728-3816
Olivier Scatton http://orcid.org/0000-0001-8313-3500
Jean-Christophe Vaillant http://orcid.org/0000-0003-0563-120X
Vladimir Alexei Morozov http://orcid.org/0000-0001-7013-7115
Stanislas Pol http://orcid.org/0000-0001-9772-9591
Sylvie Lagaye http://orcid.org/0000-0002-9156-3698
Funding Agency and Grant Number
Funding Agency Grant Number
Institut National de la Santé et de la Recherche Médicale (INSERM, France) and by Institut Pasteur (Paris, France)
PhD Fellowship from Assistance Publique-Hôpitaux de Paris (AP-HP, France)
Corresponding Author Sylvie Lagaye, DSc, PhD, Senior Scientist, Institut Pasteur, Immunobiologie des Cellules Dendritiques, INSERM U1223, 25-28 rue du Dr Roux, Paris 75015, France. sylvie.lagaye@inserm.fr
Key Words Human liver fibrosis; Hepatitis C virus; Alcoholic liver disease; Nonalcoholic steatohepatitis; Ex vivo model; Drugs
Core Tip In the developed world, about 45% of deaths are due to fibroproliferative diseases. Liver fibrosis is frequently associated with viral infection (Hepatitis C virus and Hepatitis B virus infection), chronic inflammation and excessive alcohol consumption. Despite the availability of effective antiviral drugs, morbidity, and mortality related to viral hepatitis are still increasing. Moreover, the number of non-viral liver diseases such as nonalcoholic steatohepatitis, and alcoholic liver disease is steadily growing. Our studies provide the proof of concept that the three-dimensional ex vivo model of human liver slice culture can be used for the molecular investigation of fibrosis as well as to perform follow-up studies of new anti-fibrotic drugs and therapies for a 21-d period.
Publish Date 2021-02-25 15:45
Citation Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Massault PP, Scatton O, Vaillant JC, Morozov VA, Stanislas P, Lagaye S. Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs. World J Hepatol 2021; 13(2): 187-217
URL https://www.wjgnet.com/1948-5182/full/v13/i2/187.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i2.187
Full Article (PDF) WJH-13-187.pdf
Full Article (Word) WJH-13-187.docx
Manuscript File 59138_Auto_Edited.docx
Answering Reviewers 59138-Answering reviewers.pdf
Audio Core Tip 59138-Audio core tip.m4a
Biostatistics Review Certificate 59138-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59138-Conflict-of-interest statement.pdf
Copyright License Agreement 59138-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59138-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 59138-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59138-Language certificate.pdf
Peer-review Report 59138-Peer-review(s).pdf
Scientific Misconduct Check 59138-Scientific misconduct check.pdf
Scientific Editor Work List 59138-Scientific editor work list.pdf