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1/21/2021 3:12:07 AM | Browse: 454 | Download: 499
Publication Name World Journal of Stem Cells
Manuscript ID 59244
Country China
Received
2020-09-01 03:05
Peer-Review Started
2020-09-01 03:05
To Make the First Decision
Return for Revision
2020-09-15 22:35
Revised
2020-11-01 01:10
Second Decision
2020-11-17 12:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-17 22:54
Articles in Press
2020-11-17 22:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-30 23:54
Typeset the Manuscript
2021-01-18 06:21
Publish the Manuscript Online
2021-01-21 03:12
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Transcriptomic alterations underline aging of osteogenic bone marrow stromal cells
Manuscript Source Invited Manuscript
All Author List Yu-Hao Cheng, Shu-Fen Liu, Jing-Cheng Dong and Qin Bian
ORCID
Author(s) ORCID Number
Yu-Hao Cheng http://orcid.org/0000-0002-7472-8518
Shu-Fen Liu http://orcid.org/0000-0001-5037-2169
Jing-Cheng Dong http://orcid.org/0000-0002-3645-0324
Qin Bian http://orcid.org/0000-0003-4190-0913
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81573992
Corresponding Author Qin Bian, MD, PhD, Professor, Department of Integrative Medicine, Huashan Hospital, Fudan University, Middle Wulumuqi Rd, Shanghai 200040, China. bianqin213@126.com
Key Words Bone marrow stromal cell; Mesenchymal stem cell; Mesenchymal stromal cell; Aging; Bone modeling and remodeling; Transcriptome
Core Tip Multipotent bone marrow stromal cells (BMSCs) are adult stem cells that form functional osteoblasts and play a critical role in bone remodeling. During aging, an increase in bone loss and reduction in structural integrity lead to osteoporosis and result in an increased risk of fracture. In this study, we examined age-dependent histological changes in murine vertebrae and uncovered that bone loss begins as early as the age of one month. The BMSCs isolated at different ages revealed a consistent decreasing trend in both colony-forming and osteogenic commitment capacity. Moreover, we obtained the transcriptomic profiles of BMSCs at 1 mo, 3 mo, and 7 mo to investigate the distinct molecular and regulatory features underpin the early loss of osteogenic potential. We showed the enrichment of osteoblastic regulation genes at one month and loss of osteogenic features at three months. The adipogenic and DNA repair features were enriched in the later age at seven months. Moreover, we demonstrated that the WNT and MAPK signaling pathways were upregulated at one month, followed by increased pro-inflammatory and apoptotic features.
Publish Date 2021-01-21 03:12
Citation Cheng YH, Liu S, Dong JC, Bian Q. Transcriptomic alterations underline aging of osteogenic bone marrow stromal cells. World J Stem Cells 2021; 13(1): 128-138
URL https://www.wjgnet.com/1948-0210/full/v13/i1/128.htm
DOI https://dx.doi.org/10.4252/wjsc.v13.i1.128
Full Article (PDF) WJSC-13-128.pdf
Full Article (Word) WJSC-13-128.docx
Manuscript File 59244_Auto_Edited_WangTQ.docx
Answering Reviewers 59244-Answering reviewers.pdf
Audio Core Tip 59244-Audio core tip.m4a
Biostatistics Review Certificate 59244-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59244-Conflict-of-interest statement.pdf
Copyright License Agreement 59244-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59244-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 59244-Institutional animal care and use committee statement.pdf
Peer-review Report 59244-Peer-review(s).pdf
Scientific Misconduct Check 59244-Scientific misconduct check.pdf
Scientific Editor Work List 59244-Scientific editor work list.pdf