| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Natsuki Ishida, Takahiro Miyazu, Satoshi Tamura, Satoshi Suzuki, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Satoshi Osawa, Yasushi Hamaya, Kazuya Shinmura, Haruhiko Sugimura, Katsutoshi Miura, Takahisa Furuta and Ken Sugimoto |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ken Sugimoto, MD, PhD, Associate Professor, First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1, Handayama, Hamamatsu 431-3192, Japan. sugimken@hama-med.ac.jp |
| Key Words |
Tuberous sclerosis complex; Neuroendocrine carcinoma; Neuroendocrine tumor; mTOR inhibitor; Esophagogastric junction; Chemotherapy |
| Core Tip |
Although it has been reported that neuroendocrine tumors can merge with the tuberous sclerosis complex (TSC), the co-occurrence of neuroendocrine carcinoma (NEC) with TSC is rare. This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC. This highly suggestive case indicates there is a difference in the occurrence of neuroendocrine tumors and NECs, which depends upon the pathogenesis of TSC developed despite inhibition of the AKT/mTOR pathway. |
| Publish Date |
2020-12-04 06:04 |
| Citation |
Ishida N, Miyazu T, Tamura S, Suzuki S, Tani S, Yamade M, Iwaizumi M, Osawa S, Hamaya Y, Shinmura K, Sugimura H, Miura K, Furuta T, Sugimoto K. Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction: A case report. World J Gastroenterol 2020; 26(45): 7263-7271 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i45/7263.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i45.7263 |
