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12/25/2020 10:20:16 AM | Browse: 430 | Download: 982
Publication Name World Journal of Gastroenterology
Manuscript ID 59582
Country/Territory China
Received
2020-09-28 03:40
Peer-Review Started
2020-09-28 03:40
To Make the First Decision
Return for Revision
2020-11-08 06:31
Revised
2020-11-19 08:16
Second Decision
2020-12-02 11:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-12-06 01:49
Articles in Press
2020-12-06 01:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-12-10 21:14
Typeset the Manuscript
2020-12-23 04:21
Publish the Manuscript Online
2020-12-25 10:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Emergency Medicine
Manuscript Type Basic Study
Article Title Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling
Manuscript Source Unsolicited Manuscript
All Author List Yun Huang, Meng-Meng Wang, Zhi-Zhou Yang, Yi Ren, Wei Zhang, Zhao-Rui Sun and Shi-Nan Nie
ORCID
Author(s) ORCID Number
Yun Huang http://orcid.org/0000-0001-6053-3413
Meng-Meng Wang http://orcid.org/0000-0002-2908-6480
Zhi-Zhou Yang http://orcid.org/0000-0003-3633-1381
Yi Ren http://orcid.org/0000-0002-4967-1476
Wei Zhang http://orcid.org/0000-0003-0914-4855
Zhao-Rui Sun http://orcid.org/0000-0002-8969-498X
Shi-Nan Nie http://orcid.org/0000-0002-9989-4766
Funding Agency and Grant Number
Funding Agency Grant Number
Social Development Projects of Jiangsu Province BE2017720
National Natural Science Foundation of China 81701894
Jiangsu Provincial Medical Youth Talent QNRC2016909
Natural Science Foundation of Jiangsu Province BK20190247
Science Foundation of Jiangsu Health Commission H2018039
China Postdoctoral Science Foundation 2018M643890
Jiangsu Postdoctoral Science Foundation 2018K048A
Jiangsu Provincial Medical Youth Talent QNRC2016908
Jiangsu Postdoctoral Science Foundation 2020Z193
Corresponding Author Shi-Nan Nie, MD, PhD, Director, Professor, Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. shn_nie@sina.com
Key Words Intestinal trefoil factor; Water immersion restraint stress; Gastric mucosa; Epithelium integrity; Akt signaling pathway
Core Tip Stress-related gastric mucosal damage remains an issue for critical care patients. As an endogenous peptide, intestinal trefoil factor was found to alleviate both macroscopic and microscopic gastric mucosal damage in vivo induced by acute stress stimulation, and promote mucosal epithelial cell survival, accelerate wound closure, and preserve mucosal integrity in vitro, in which the Akt signaling pathway could play the essential roles. Therefore, intestinal trefoil factor was a promising candidate for prevention and treatment of stress-induced gastric mucosal damage.
Publish Date 2020-12-25 10:20
Citation Huang Y, Wang MM, Yang ZZ, Ren Y, Zhang W, Sun ZR, Nie SN. Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling. World J Gastroenterol 2020; 26(48): 7619-7632
URL https://www.wjgnet.com/1007-9327/full/v26/i48/7619.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i48.7619
Full Article (PDF) WJG-26-7619.pdf
Full Article (Word) WJG-26-7619.docx
The ARRIVE Guidelines 59582-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 59582-Review-Filipodia.docx
Answering Reviewers 59582-Answering reviewers.pdf
Audio Core Tip 59582-Audio core tip.mp3
Biostatistics Review Certificate 59582-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59582-Conflict-of-interest statement.pdf
Copyright License Agreement 59582-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59582-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 59582-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 59582-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59582-Language certificate.pdf
Peer-review Report 59582-Peer-review(s).pdf
Scientific Misconduct Check 59582-Bing-Yan JP-1.png
Scientific Misconduct Check 59582-Scientific misconduct check.pdf
Scientific Editor Work List 59582-Scientific editor work list.pdf