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8/26/2014 5:16:00 PM | Browse: 1134 | Download: 968
Publication Name World Journal of Gastroenterology
Manuscript ID 5960
Country/Territory Hungary
Received
2013-09-29 08:37
Peer-Review Started
2013-09-29 08:42
To Make the First Decision
2013-12-16 17:09
Return for Revision
2013-12-17 15:12
Revised
2014-01-08 21:32
Second Decision
2014-04-03 10:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-03 12:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-06 15:34
Publish the Manuscript Online
2014-05-28 11:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Role of antispasmodics in the treatment of irritable bowel syndrome
Manuscript Source Invited Manuscript
All Author List Anita Annaházi, Richárd Róka, András Rosztóczy and Tibor Wittmann
Funding Agency and Grant Number
Corresponding Author Tibor Wittmann, MD, PhD, Professor, First Department of Medicine, University of Szeged, Korányi fasor 8-10, 6720 Szeged, Hungary. wittmann.tibor@med.u-szeged.hu
Key Words Irritable bowel syndrome; Motility; Treatment; Calcium channel blockers; Spasmolytics
Core Tip Treatment of irritable bowel syndrome (IBS) must target intestinal motility alterations and visceral hypersensitivity. Antispasmodics have been used in the treatment of IBS for decades, and large placebo-controlled trials have recently been conducted on their efficacy. Alverine citrate, in combination with simethicone, effectively reduced abdominal pain and discomfort; while otilonium bromide also improved defecation problems. Pinaverium bromide regulated impaired motility and reduced stool complaints. Phloroglucinol and trimethylphloroglucinol reduced pain in IBS patients. Mebeverine was recently found to be effective only in non-placebo-controlled trials. Antispasmodics are considered safe. T-type calcium channel blockers could represent a future therapeutic option in IBS treatment.
Publish Date 2014-05-28 11:45
Citation Annaházi A, Róka R, Rosztóczy A, Wittmann T. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol 2014; 20(20): 6031-6043
URL http://www.wjgnet.com/1007-9327/full/v20/i20/6031.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i20.6031
Full Article (PDF) WJG-20-6031.pdf
Full Article (Word) WJG-20-6031.doc
Manuscript File 5960-Review.doc
Answering Reviewers 5960-Answering reviewers.pdf
Copyright License Agreement 5960-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 5960-Language certificate.pdf
Peer-review Report 5960-Peer reviews.pdf
Scientific Editor Work List 5960-Scientific editor work list.doc